Hemodynamic response to continuous infusion of dobutamine in Alagille's syndrome.

TY - JOUR

T1 - Hemodynamic response to continuous infusion of dobutamine in Alagille's syndrome.

AU - Razavi, R S

AU - Baker, A

AU - Qureshi, S A

AU - Rosenthal, E

AU - Marsh, M J

AU - Leech, S C

AU - Rela, M

AU - Mieli-Vergani, G

PY - 2001

Y1 - 2001

N2 - Background. Alagille's syndrome is a rare condition that is characterized by paucity of interlobular bile ducts and peripheral pulmonary artery stenosis. Liver transplantation in the setting of peripheral pulmonary stenosis and right ventricular hypertension seems to be associated with a higher mortality, which raises the concern that these patients are unable to increase their cardiac output in the immediate posttransplantation period to meet the demands of reperfusion and early graft dysfunction and cope with further increases in pulmonary vascular resistance. Method. Cardiac catheterization was performed in 15 children with Alagille's syndrome and peripheral pulmonary artery stenosis to measure the cardiac output response to dobutamine infusion. The cardiac output was measured before and during each increment of infusion of dobutamine at 10 mug/kg/min and 20 mug/kg/min by using a thermodilution catheter placed in the pulmonary artery. Results. There was a significant change in the baseline cardiac index (P

AB - Background. Alagille's syndrome is a rare condition that is characterized by paucity of interlobular bile ducts and peripheral pulmonary artery stenosis. Liver transplantation in the setting of peripheral pulmonary stenosis and right ventricular hypertension seems to be associated with a higher mortality, which raises the concern that these patients are unable to increase their cardiac output in the immediate posttransplantation period to meet the demands of reperfusion and early graft dysfunction and cope with further increases in pulmonary vascular resistance. Method. Cardiac catheterization was performed in 15 children with Alagille's syndrome and peripheral pulmonary artery stenosis to measure the cardiac output response to dobutamine infusion. The cardiac output was measured before and during each increment of infusion of dobutamine at 10 mug/kg/min and 20 mug/kg/min by using a thermodilution catheter placed in the pulmonary artery. Results. There was a significant change in the baseline cardiac index (P

U2 - 10.1097/00007890-200109150-00014

DO - 10.1097/00007890-200109150-00014

M3 - Article

VL - 72

SP - 823

EP - 828

JO - Transplantation

JF - Transplantation

IS - 5

ER -