HER2 mediates PSMA/mGluR1-driven resistance to the DS-7423 dual 2 PI3K/mTOR inhibitor in PTEN wild-type prostate cancer models: PTEN-wt PCa overcomes PI3K inhibition via mGluR1 signaling

Valentí Gómez, Myria Galazi, Gregory Weitsman, James Monypenny of Pitmilly, Fahad Al-Salemee, Paul Barber, Kenrick Ng, Richard Beatson, Bálint Szokol, László Orfi, Gregory Mullen, Bart Vanhaesebroeck, Simon Chowdhury, Hing Y Leung, Tony Ng*

*Corresponding author for this work

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Pharmacology, Toxicology and Pharmaceutical Science