Heritability of the limbic networks

Sanja Budisavljevic; Jamie Michelle Kawadler; Flavio Dell' Acqua; Fruhling Vesta Rijsdijk; Fergus Kane; Mark Michael Picchioni; Philip McGuire; Timothea Toulopoulou; Anna Georgiades; S Kalidindi; Eugenia Kravariti; Robin MacGregor Murray; Declan G Murphy; Michael Cohen Craig; Marco Catani

doi:10.1093/scan/nsv156

Heritability of the limbic networks

Sanja Budisavljevic, Jamie Michelle Kawadler, Flavio Dell' Acqua, Fruhling Vesta Rijsdijk, Fergus Kane, Mark Michael Picchioni, Philip McGuire, Timothea Toulopoulou, Anna Georgiades, S Kalidindi, Eugenia Kravariti, Robin MacGregor Murray, Declan G Murphy, Michael Cohen Craig, Marco Catani

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Abstract

Individual differences in cognitive ability and social behaviour are influenced by the variability in the structure and function of the limbic system. A strong heritability of the limbic cortex has been previously reported, but little is known about how genetic factors influence specific limbic networks. We used diffusion tensor imaging tractography to investigate heritability of different limbic tracts in 52 monozygotic and 34 dizygotic healthy adult twins. We explored the connections that contribute to the activity of three distinct functional limbic networks, namely the dorsal cingulum (‘medial default-mode network’), the ventral cingulum and the fornix (‘hippocampal-diencephalic-retrosplenial network’) and the uncinate fasciculus (‘temporo-amygdala-orbitofrontal network’). Genetic and environmental variances were mapped for multiple tract-specific measures that reflect different aspects of the underlying anatomy. We report the highest heritability for the uncinate fasciculus, a tract that underpins emotion processing, semantic cognition, and social behaviour. High to moderate genetic and shared environmental effects were found for pathways important for social behaviour and memory, for example, fornix, dorsal and ventral cingulum. These findings indicate that within the limbic system inheritance of specific traits may rely on the anatomy of distinct networks and is higher for fronto-temporal pathways dedicated to complex social behaviour and emotional processing.

Original language	English
Pages (from-to)	746-757
Journal	Social Cognitive and Affective Neuroscience
Volume	11
Issue number	5
Early online date	28 Dec 2015
DOIs	https://doi.org/10.1093/scan/nsv156
Publication status	Published - 5 May 2016

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Heritability of the limbic networks_BUDISAVLJEVIC_Accepted16December2015_GOLD VoRFinal published version, 667 KBLicence: CC BY

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Budisavljevic, S., Kawadler, J. M., Dell' Acqua, F., Rijsdijk, F. V., Kane, F., Picchioni, M. M., McGuire, P., Toulopoulou, T., Georgiades, A., Kalidindi, S., Kravariti, E., Murray, R. M., Murphy, D. G., Craig, M. C., & Catani, M. (2016). Heritability of the limbic networks. Social Cognitive and Affective Neuroscience, 11(5), 746-757. https://doi.org/10.1093/scan/nsv156

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AU - Kane, Fergus

AU - Picchioni, Mark Michael

AU - McGuire, Philip

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Heritability of the limbic networks

Abstract

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