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Heritability of the limbic networks

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Heritability of the limbic networks. / Budisavljevic, Sanja; Kawadler, Jamie Michelle; Dell' Acqua, Flavio; Rijsdijk, Fruhling Vesta; Kane, Fergus; Picchioni, Mark Michael; McGuire, Philip; Toulopoulou, Timothea; Georgiades, Anna; Kalidindi, S; Kravariti, Eugenia; Murray, Robin MacGregor; Murphy, Declan G; Craig, Michael Cohen; Catani, Marco.

In: Social Cognitive and Affective Neuroscience, Vol. 11, No. 5, 05.05.2016, p. 746-757.

Research output: Contribution to journalArticle

Harvard

Budisavljevic, S, Kawadler, JM, Dell' Acqua, F, Rijsdijk, FV, Kane, F, Picchioni, MM, McGuire, P, Toulopoulou, T, Georgiades, A, Kalidindi, S, Kravariti, E, Murray, RM, Murphy, DG, Craig, MC & Catani, M 2016, 'Heritability of the limbic networks', Social Cognitive and Affective Neuroscience, vol. 11, no. 5, pp. 746-757. https://doi.org/10.1093/scan/nsv156

APA

Budisavljevic, S., Kawadler, J. M., Dell' Acqua, F., Rijsdijk, F. V., Kane, F., Picchioni, M. M., ... Catani, M. (2016). Heritability of the limbic networks. Social Cognitive and Affective Neuroscience, 11(5), 746-757. https://doi.org/10.1093/scan/nsv156

Vancouver

Budisavljevic S, Kawadler JM, Dell' Acqua F, Rijsdijk FV, Kane F, Picchioni MM et al. Heritability of the limbic networks. Social Cognitive and Affective Neuroscience. 2016 May 5;11(5):746-757. https://doi.org/10.1093/scan/nsv156

Author

Budisavljevic, Sanja ; Kawadler, Jamie Michelle ; Dell' Acqua, Flavio ; Rijsdijk, Fruhling Vesta ; Kane, Fergus ; Picchioni, Mark Michael ; McGuire, Philip ; Toulopoulou, Timothea ; Georgiades, Anna ; Kalidindi, S ; Kravariti, Eugenia ; Murray, Robin MacGregor ; Murphy, Declan G ; Craig, Michael Cohen ; Catani, Marco. / Heritability of the limbic networks. In: Social Cognitive and Affective Neuroscience. 2016 ; Vol. 11, No. 5. pp. 746-757.

Bibtex Download

@article{00fee96851ea4d29b381d5d0413b2bc0,
title = "Heritability of the limbic networks",
abstract = "Individual differences in cognitive ability and social behaviour are influenced by the variability in the structure and function of the limbic system. A strong heritability of the limbic cortex has been previously reported, but little is known about how genetic factors influence specific limbic networks. We used diffusion tensor imaging tractography to investigate heritability of different limbic tracts in 52 monozygotic and 34 dizygotic healthy adult twins. We explored the connections that contribute to the activity of three distinct functional limbic networks, namely the dorsal cingulum (‘medial default-mode network’), the ventral cingulum and the fornix (‘hippocampal-diencephalic-retrosplenial network’) and the uncinate fasciculus (‘temporo-amygdala-orbitofrontal network’). Genetic and environmental variances were mapped for multiple tract-specific measures that reflect different aspects of the underlying anatomy. We report the highest heritability for the uncinate fasciculus, a tract that underpins emotion processing, semantic cognition, and social behaviour. High to moderate genetic and shared environmental effects were found for pathways important for social behaviour and memory, for example, fornix, dorsal and ventral cingulum. These findings indicate that within the limbic system inheritance of specific traits may rely on the anatomy of distinct networks and is higher for fronto-temporal pathways dedicated to complex social behaviour and emotional processing.",
author = "Sanja Budisavljevic and Kawadler, {Jamie Michelle} and {Dell' Acqua}, Flavio and Rijsdijk, {Fruhling Vesta} and Fergus Kane and Picchioni, {Mark Michael} and Philip McGuire and Timothea Toulopoulou and Anna Georgiades and S Kalidindi and Eugenia Kravariti and Murray, {Robin MacGregor} and Murphy, {Declan G} and Craig, {Michael Cohen} and Marco Catani",
year = "2016",
month = "5",
day = "5",
doi = "10.1093/scan/nsv156",
language = "English",
volume = "11",
pages = "746--757",
journal = "Social Cognitive and Affective Neuroscience",
issn = "1749-5016",
publisher = "OXFORD UNIV PRESS",
number = "5",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Heritability of the limbic networks

AU - Budisavljevic, Sanja

AU - Kawadler, Jamie Michelle

AU - Dell' Acqua, Flavio

AU - Rijsdijk, Fruhling Vesta

AU - Kane, Fergus

AU - Picchioni, Mark Michael

AU - McGuire, Philip

AU - Toulopoulou, Timothea

AU - Georgiades, Anna

AU - Kalidindi, S

AU - Kravariti, Eugenia

AU - Murray, Robin MacGregor

AU - Murphy, Declan G

AU - Craig, Michael Cohen

AU - Catani, Marco

PY - 2016/5/5

Y1 - 2016/5/5

N2 - Individual differences in cognitive ability and social behaviour are influenced by the variability in the structure and function of the limbic system. A strong heritability of the limbic cortex has been previously reported, but little is known about how genetic factors influence specific limbic networks. We used diffusion tensor imaging tractography to investigate heritability of different limbic tracts in 52 monozygotic and 34 dizygotic healthy adult twins. We explored the connections that contribute to the activity of three distinct functional limbic networks, namely the dorsal cingulum (‘medial default-mode network’), the ventral cingulum and the fornix (‘hippocampal-diencephalic-retrosplenial network’) and the uncinate fasciculus (‘temporo-amygdala-orbitofrontal network’). Genetic and environmental variances were mapped for multiple tract-specific measures that reflect different aspects of the underlying anatomy. We report the highest heritability for the uncinate fasciculus, a tract that underpins emotion processing, semantic cognition, and social behaviour. High to moderate genetic and shared environmental effects were found for pathways important for social behaviour and memory, for example, fornix, dorsal and ventral cingulum. These findings indicate that within the limbic system inheritance of specific traits may rely on the anatomy of distinct networks and is higher for fronto-temporal pathways dedicated to complex social behaviour and emotional processing.

AB - Individual differences in cognitive ability and social behaviour are influenced by the variability in the structure and function of the limbic system. A strong heritability of the limbic cortex has been previously reported, but little is known about how genetic factors influence specific limbic networks. We used diffusion tensor imaging tractography to investigate heritability of different limbic tracts in 52 monozygotic and 34 dizygotic healthy adult twins. We explored the connections that contribute to the activity of three distinct functional limbic networks, namely the dorsal cingulum (‘medial default-mode network’), the ventral cingulum and the fornix (‘hippocampal-diencephalic-retrosplenial network’) and the uncinate fasciculus (‘temporo-amygdala-orbitofrontal network’). Genetic and environmental variances were mapped for multiple tract-specific measures that reflect different aspects of the underlying anatomy. We report the highest heritability for the uncinate fasciculus, a tract that underpins emotion processing, semantic cognition, and social behaviour. High to moderate genetic and shared environmental effects were found for pathways important for social behaviour and memory, for example, fornix, dorsal and ventral cingulum. These findings indicate that within the limbic system inheritance of specific traits may rely on the anatomy of distinct networks and is higher for fronto-temporal pathways dedicated to complex social behaviour and emotional processing.

U2 - 10.1093/scan/nsv156

DO - 10.1093/scan/nsv156

M3 - Article

VL - 11

SP - 746

EP - 757

JO - Social Cognitive and Affective Neuroscience

JF - Social Cognitive and Affective Neuroscience

SN - 1749-5016

IS - 5

ER -

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