High Asymptomatic Carriage With the Omicron Variant in South Africa

on behalf of the Ubuntu Study Team

doi:10.1093/cid/ciac237

High Asymptomatic Carriage With the Omicron Variant in South Africa

on behalf of the Ubuntu Study Team

Population Health Sciences

University of Kwazulu-Natal
Fred Hutchinson Cancer Center
Washington University in St Louis
South African Medical Research Council
Bio Analytical Research Corporation South Africa and Lancet Laboratories
NIAID National Institute of Allergy and Infectious Diseases, National Institutes of Health
University of Pretoria
University of Washington
Qhakaza Mbokodo Research Clinic
University of Cape Town

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4+T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.

Original language	English
Pages (from-to)	E289-E292
Journal	Clinical Infectious Diseases
Volume	75
Issue number	1
DOIs	https://doi.org/10.1093/cid/ciac237
Publication status	Published - 1 Jul 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

asymptomatic carriage
Omicron variant
PWH
SARS-CoV-2
South Africa

Access to Document

10.1093/cid/ciac237

Cite this

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title = "High Asymptomatic Carriage With the Omicron Variant in South Africa",

abstract = "We report a 23\% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4+T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.",

keywords = "asymptomatic carriage, Omicron variant, PWH, SARS-CoV-2, South Africa",

author = "Nigel Garrett and Asa Tapley and Jessica Andriesen and Ishen Seocharan and Fisher, \{Leigh H.\} and Lisa Bunts and Nicole Espy and Wallis, \{Carole L.\} and Randhawa, \{April Kaur\} and Miner, \{Maurine D.\} and Nzeera Ketter and Margaret Yacovone and Ameena Goga and Yunda Huang and John Hural and Philip Kotze and Bekker, \{Linda Gail\} and Gray, \{Glenda E.\} and Lawrence Corey and Khatija Ahmed and Sharlaa Badal-Faesen and Shaun Barnabas and William Brumskine and Kim Comline and Andreas Diacon and Thozama Dubula and Katherine Gill and Coert Grobbelaar and Craig Innes and Sheetal Kassim and Sheena Kotze and Erica Lazarus and Johannes Lombaard and Angelique Luabeya and Maboa, \{Rebone Molobane\} and Scott Mahoney and Disebo Mahkaza and Moelo Malahleha and Daniel Malan and Kathryn Mngadi and Nivashnee Naicker and Vimla Naicker and Logashvari Naidoo and Maphoshane Nchabeleng and Mohammed Rassool and Elizabeth Spooner and Hugo Tempelman and Nyaradzo Mgodi and Sufia Dadabhai and Lara Fairall and \{on behalf of the Ubuntu Study Team\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America.",

year = "2022",

month = jul,

day = "1",

doi = "10.1093/cid/ciac237",

language = "English",

volume = "75",

pages = "E289--E292",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

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T1 - High Asymptomatic Carriage With the Omicron Variant in South Africa

AU - Garrett, Nigel

AU - Tapley, Asa

AU - Andriesen, Jessica

AU - Seocharan, Ishen

AU - Fisher, Leigh H.

AU - Bunts, Lisa

AU - Espy, Nicole

AU - Wallis, Carole L.

AU - Randhawa, April Kaur

AU - Miner, Maurine D.

AU - Ketter, Nzeera

AU - Yacovone, Margaret

AU - Goga, Ameena

AU - Huang, Yunda

AU - Hural, John

AU - Kotze, Philip

AU - Bekker, Linda Gail

AU - Gray, Glenda E.

AU - Corey, Lawrence

AU - Ahmed, Khatija

AU - Badal-Faesen, Sharlaa

AU - Barnabas, Shaun

AU - Brumskine, William

AU - Comline, Kim

AU - Diacon, Andreas

AU - Dubula, Thozama

AU - Gill, Katherine

AU - Grobbelaar, Coert

AU - Innes, Craig

AU - Kassim, Sheetal

AU - Kotze, Sheena

AU - Lazarus, Erica

AU - Lombaard, Johannes

AU - Luabeya, Angelique

AU - Maboa, Rebone Molobane

AU - Mahoney, Scott

AU - Mahkaza, Disebo

AU - Malahleha, Moelo

AU - Malan, Daniel

AU - Mngadi, Kathryn

AU - Naicker, Nivashnee

AU - Naicker, Vimla

AU - Naidoo, Logashvari

AU - Nchabeleng, Maphoshane

AU - Rassool, Mohammed

AU - Spooner, Elizabeth

AU - Tempelman, Hugo

AU - Mgodi, Nyaradzo

AU - Dadabhai, Sufia

AU - Fairall, Lara

AU - on behalf of the Ubuntu Study Team

PY - 2022/7/1

Y1 - 2022/7/1

N2 - We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4+T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.

AB - We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4+T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.

KW - asymptomatic carriage

KW - Omicron variant

KW - PWH

KW - SARS-CoV-2

KW - South Africa

UR - https://www.scopus.com/pages/publications/85131085262

U2 - 10.1093/cid/ciac237

DO - 10.1093/cid/ciac237

M3 - Article

C2 - 35353885

AN - SCOPUS:85131085262

SN - 1058-4838

VL - 75

SP - E289-E292

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 1

ER -

High Asymptomatic Carriage With the Omicron Variant in South Africa

Abstract

UN SDGs

Keywords

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