TY - JOUR
T1 - High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders
AU - Fiford, Cassidy M.
AU - Nicholas, Jennifer M.
AU - Biessels, Geert Jan
AU - Lane, Christopher A.
AU - Cardoso, M. Jorge
AU - Barnes, Josephine
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Introduction: Understanding relationships among blood pressure (BP), cognition, and brain volume could inform Alzheimer's disease (AD) management. Methods: We investigated Alzheimer's Disease Neuroimaging Initiative (ADNI) participants: 200 controls, 346 mild cognitive impairment (MCI), and 154 AD. National Alzheimer's Co-ordinating Center (NACC) participants were separately analyzed: 1098 controls, 2297 MCI, and 4845 AD. Relationships between cognition and BP were assessed in both cohorts and BP and atrophy rates in ADNI. Multivariate mixed linear-regression models were fitted with joint outcomes of BP (systolic, diastolic, and pulse pressure), cognition (Mini-Mental State Examination, Logical Memory, and Digit Symbol) and atrophy rate (whole-brain, hippocampus). Results: ADNI MCI and AD patients with greater baseline systolic BP had higher hippocampal atrophy rates ([r, P value]; 0.2, 0.005 and 0.2, 0.04, respectively). NACC AD patients with lower systolic BP had lower cognitive scores (0.1, 0.0003). Discussion: Higher late-life BP may be associated with faster decline in cognitively impaired elders.
AB - Introduction: Understanding relationships among blood pressure (BP), cognition, and brain volume could inform Alzheimer's disease (AD) management. Methods: We investigated Alzheimer's Disease Neuroimaging Initiative (ADNI) participants: 200 controls, 346 mild cognitive impairment (MCI), and 154 AD. National Alzheimer's Co-ordinating Center (NACC) participants were separately analyzed: 1098 controls, 2297 MCI, and 4845 AD. Relationships between cognition and BP were assessed in both cohorts and BP and atrophy rates in ADNI. Multivariate mixed linear-regression models were fitted with joint outcomes of BP (systolic, diastolic, and pulse pressure), cognition (Mini-Mental State Examination, Logical Memory, and Digit Symbol) and atrophy rate (whole-brain, hippocampus). Results: ADNI MCI and AD patients with greater baseline systolic BP had higher hippocampal atrophy rates ([r, P value]; 0.2, 0.005 and 0.2, 0.04, respectively). NACC AD patients with lower systolic BP had lower cognitive scores (0.1, 0.0003). Discussion: Higher late-life BP may be associated with faster decline in cognitively impaired elders.
KW - Alzheimer's disease
KW - blood pressure
KW - cognitive decline
KW - hypertension
KW - hypotension
KW - longitudinal
KW - mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85084968732&partnerID=8YFLogxK
U2 - 10.1002/dad2.12035
DO - 10.1002/dad2.12035
M3 - Article
AN - SCOPUS:85084968732
SN - 2352-8729
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
ER -