High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders

Cassidy M. Fiford, Jennifer M. Nicholas, Geert Jan Biessels, Christopher A. Lane, M. Jorge Cardoso, Josephine Barnes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Introduction: Understanding relationships among blood pressure (BP), cognition, and brain volume could inform Alzheimer's disease (AD) management. Methods: We investigated Alzheimer's Disease Neuroimaging Initiative (ADNI) participants: 200 controls, 346 mild cognitive impairment (MCI), and 154 AD. National Alzheimer's Co-ordinating Center (NACC) participants were separately analyzed: 1098 controls, 2297 MCI, and 4845 AD. Relationships between cognition and BP were assessed in both cohorts and BP and atrophy rates in ADNI. Multivariate mixed linear-regression models were fitted with joint outcomes of BP (systolic, diastolic, and pulse pressure), cognition (Mini-Mental State Examination, Logical Memory, and Digit Symbol) and atrophy rate (whole-brain, hippocampus). Results: ADNI MCI and AD patients with greater baseline systolic BP had higher hippocampal atrophy rates ([r, P value]; 0.2, 0.005 and 0.2, 0.04, respectively). NACC AD patients with lower systolic BP had lower cognitive scores (0.1, 0.0003). Discussion: Higher late-life BP may be associated with faster decline in cognitively impaired elders.

Original languageEnglish
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
DOIs
Publication statusAccepted/In press - 1 Jan 2020

Keywords

  • Alzheimer's disease
  • blood pressure
  • cognitive decline
  • hypertension
  • hypotension
  • longitudinal
  • mild cognitive impairment

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