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High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population

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High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population. / Wijesuriya, Mahen; Gulliford, Martin; Charlton, Judith; Vasantharaja, Laksha; Viberti, Giancarlo; Gnudi, Luigi; Karalliedde, Janaka.

In: PL o S One , Vol. 7, No. 2, e31309, 13.02.2012.

Research output: Contribution to journalArticle

Harvard

Wijesuriya, M, Gulliford, M, Charlton, J, Vasantharaja, L, Viberti, G, Gnudi, L & Karalliedde, J 2012, 'High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population', PL o S One , vol. 7, no. 2, e31309. https://doi.org/10.1371/journal.pone.0031309

APA

Wijesuriya, M., Gulliford, M., Charlton, J., Vasantharaja, L., Viberti, G., Gnudi, L., & Karalliedde, J. (2012). High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population. PL o S One , 7(2), [e31309]. https://doi.org/10.1371/journal.pone.0031309

Vancouver

Wijesuriya M, Gulliford M, Charlton J, Vasantharaja L, Viberti G, Gnudi L et al. High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population. PL o S One . 2012 Feb 13;7(2). e31309. https://doi.org/10.1371/journal.pone.0031309

Author

Wijesuriya, Mahen ; Gulliford, Martin ; Charlton, Judith ; Vasantharaja, Laksha ; Viberti, Giancarlo ; Gnudi, Luigi ; Karalliedde, Janaka. / High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population. In: PL o S One . 2012 ; Vol. 7, No. 2.

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@article{872e0a799fc847268e7c522a421e39dc,
title = "High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population",
abstract = "Background: South-Asian's are predisposed to early onset type 2 diabetes (T2DM). The prevalence of cardio-metabolic risk-factors in young Sri-Lankans is unknown.Methodology/Principal Findings: To determine by questionnaire and anthropometry the prevalence of first degree family history (FH) of T2DM, physical inactivity, raised waist circumference (WC) and raised body mass index (BMI) in a representative healthy urban population selected by cluster sampling. Those with >= 2 risk-factors were evaluated for metabolic syndrome (MS) and recruited for an intervention trial. Of 23,296 participants screened, 22,507 (53{\%} Female) were eligible [8,497 aged 10-14 yrs, 4,763 aged 15-19 yrs and 9,247 aged 20-40 yrs]. 51{\%} had none of the 4 risk-factors, 26{\%} 1 risk-factor and 23{\%} (5,163) >= 2 risk-factors of whom 4,532 were assessed for MS. Raised BMI was noted in 19.7{\%} aged 10-14 yrs, 15.3{\%} between 15-19 yrs, and between 20-40 yrs, 27.4{\%} of males vs. 21.8{\%} of females p<0.001. Prevalence of raised WC was greater in females for each age group: 42.7{\%} vs. 32.1{\%}; 28.1{\%} vs. 16.1{\%}; 34.5{\%} vs. 25.7{\%} (p<0.05 for all) as was physical inactivity: 39.9{\%} vs. 14.5{\%}; 51.7{\%} vs. 20.0{\%}; 62.7{\%} vs. 41.3{\%} which rose in both sexes with age (p<0.05 for all). FH of T2DM was present in 26.2{\%}. In 4532 (50{\%}, 16 yrs) with >= 2 risk-factors, impaired fasting glycaemia/impaired glucose tolerance (pre-diabetes) prevalence was 16{\%}. MS was more prevalent in males [10-16 yrs (13.0{\%} vs. 8.8{\%}), 16-40 yrs (29.5{\%} vs. 20.0{\%}) p<0.001 for both].Conclusions/Significance: There is a high prevalence of modifiable cardio-metabolic risk-factors in young urban Sri-Lankans with significant gender differences. A primary prevention intervention trial is ongoing in this cohort. Clinical Trial Registration Number SLCTR/2008/World Health Organization (WHO) international clinical trial registry platform.",
author = "Mahen Wijesuriya and Martin Gulliford and Judith Charlton and Laksha Vasantharaja and Giancarlo Viberti and Luigi Gnudi and Janaka Karalliedde",
year = "2012",
month = "2",
day = "13",
doi = "10.1371/journal.pone.0031309",
language = "English",
volume = "7",
journal = "PL o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population

AU - Wijesuriya, Mahen

AU - Gulliford, Martin

AU - Charlton, Judith

AU - Vasantharaja, Laksha

AU - Viberti, Giancarlo

AU - Gnudi, Luigi

AU - Karalliedde, Janaka

PY - 2012/2/13

Y1 - 2012/2/13

N2 - Background: South-Asian's are predisposed to early onset type 2 diabetes (T2DM). The prevalence of cardio-metabolic risk-factors in young Sri-Lankans is unknown.Methodology/Principal Findings: To determine by questionnaire and anthropometry the prevalence of first degree family history (FH) of T2DM, physical inactivity, raised waist circumference (WC) and raised body mass index (BMI) in a representative healthy urban population selected by cluster sampling. Those with >= 2 risk-factors were evaluated for metabolic syndrome (MS) and recruited for an intervention trial. Of 23,296 participants screened, 22,507 (53% Female) were eligible [8,497 aged 10-14 yrs, 4,763 aged 15-19 yrs and 9,247 aged 20-40 yrs]. 51% had none of the 4 risk-factors, 26% 1 risk-factor and 23% (5,163) >= 2 risk-factors of whom 4,532 were assessed for MS. Raised BMI was noted in 19.7% aged 10-14 yrs, 15.3% between 15-19 yrs, and between 20-40 yrs, 27.4% of males vs. 21.8% of females p<0.001. Prevalence of raised WC was greater in females for each age group: 42.7% vs. 32.1%; 28.1% vs. 16.1%; 34.5% vs. 25.7% (p<0.05 for all) as was physical inactivity: 39.9% vs. 14.5%; 51.7% vs. 20.0%; 62.7% vs. 41.3% which rose in both sexes with age (p<0.05 for all). FH of T2DM was present in 26.2%. In 4532 (50%, 16 yrs) with >= 2 risk-factors, impaired fasting glycaemia/impaired glucose tolerance (pre-diabetes) prevalence was 16%. MS was more prevalent in males [10-16 yrs (13.0% vs. 8.8%), 16-40 yrs (29.5% vs. 20.0%) p<0.001 for both].Conclusions/Significance: There is a high prevalence of modifiable cardio-metabolic risk-factors in young urban Sri-Lankans with significant gender differences. A primary prevention intervention trial is ongoing in this cohort. Clinical Trial Registration Number SLCTR/2008/World Health Organization (WHO) international clinical trial registry platform.

AB - Background: South-Asian's are predisposed to early onset type 2 diabetes (T2DM). The prevalence of cardio-metabolic risk-factors in young Sri-Lankans is unknown.Methodology/Principal Findings: To determine by questionnaire and anthropometry the prevalence of first degree family history (FH) of T2DM, physical inactivity, raised waist circumference (WC) and raised body mass index (BMI) in a representative healthy urban population selected by cluster sampling. Those with >= 2 risk-factors were evaluated for metabolic syndrome (MS) and recruited for an intervention trial. Of 23,296 participants screened, 22,507 (53% Female) were eligible [8,497 aged 10-14 yrs, 4,763 aged 15-19 yrs and 9,247 aged 20-40 yrs]. 51% had none of the 4 risk-factors, 26% 1 risk-factor and 23% (5,163) >= 2 risk-factors of whom 4,532 were assessed for MS. Raised BMI was noted in 19.7% aged 10-14 yrs, 15.3% between 15-19 yrs, and between 20-40 yrs, 27.4% of males vs. 21.8% of females p<0.001. Prevalence of raised WC was greater in females for each age group: 42.7% vs. 32.1%; 28.1% vs. 16.1%; 34.5% vs. 25.7% (p<0.05 for all) as was physical inactivity: 39.9% vs. 14.5%; 51.7% vs. 20.0%; 62.7% vs. 41.3% which rose in both sexes with age (p<0.05 for all). FH of T2DM was present in 26.2%. In 4532 (50%, 16 yrs) with >= 2 risk-factors, impaired fasting glycaemia/impaired glucose tolerance (pre-diabetes) prevalence was 16%. MS was more prevalent in males [10-16 yrs (13.0% vs. 8.8%), 16-40 yrs (29.5% vs. 20.0%) p<0.001 for both].Conclusions/Significance: There is a high prevalence of modifiable cardio-metabolic risk-factors in young urban Sri-Lankans with significant gender differences. A primary prevention intervention trial is ongoing in this cohort. Clinical Trial Registration Number SLCTR/2008/World Health Organization (WHO) international clinical trial registry platform.

U2 - 10.1371/journal.pone.0031309

DO - 10.1371/journal.pone.0031309

M3 - Article

VL - 7

JO - PL o S One

JF - PL o S One

SN - 1932-6203

IS - 2

M1 - e31309

ER -

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