High resolution and contrast 7 tesla MR brain imaging of the neonate

Philippa Bridgen; Raphael Tomi-Tricot; Alena Uus; Daniel Cromb; Megan Quirke; Jennifer Almalbis; Beya Bonse; Miguel De la Fuente Botella; Alessandra Maggioni; Pierluigi Di Cio; Paul Cawley; Chiara Casella; Ayse Sila Dokumaci; Alice R. Thomson; Jucha Willers Moore; Devi Bridglal; Joao Saravia; Thomas Finck; Anthony N. Price; Elisabeth Pickles; Lucilio Cordero-Grande; Alexia Egloff; Jonathan O’Muircheartaigh; Serena J. Counsell; Sharon L. Giles; Maria Deprez; Enrico De Vita; Mary A. Rutherford; A. David Edwards; Joseph V. Hajnal; Shaihan J. Malik; Tomoki Arichi

doi:10.3389/fradi.2023.1327075

High resolution and contrast 7 tesla MR brain imaging of the neonate

Philippa Bridgen, Raphael Tomi-Tricot, Alena Uus, Daniel Cromb, Megan Quirke, Jennifer Almalbis, Beya Bonse, Miguel De la Fuente Botella, Alessandra Maggioni, Pierluigi Di Cio, Paul Cawley, Chiara Casella, Ayse Sila Dokumaci, Alice R. Thomson, Jucha Willers Moore, Devi Bridglal, Joao Saravia, Thomas Finck, Anthony N. Price, Elisabeth PicklesLucilio Cordero-Grande, Alexia Egloff, Jonathan O’Muircheartaigh, Serena J. Counsell, Sharon L. Giles, Maria Deprez, Enrico De Vita, Mary A. Rutherford, A. David Edwards, Joseph V. Hajnal, Shaihan J. Malik, Tomoki Arichi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Introduction: Ultra-high field MR imaging offers marked gains in signal-to-noise ratio, spatial resolution, and contrast which translate to improved pathological and anatomical sensitivity. These benefits are particularly relevant for the neonatal brain which is rapidly developing and sensitive to injury. However, experience of imaging neonates at 7T has been limited due to regulatory, safety, and practical considerations. We aimed to establish a program for safely acquiring high resolution and contrast brain images from neonates on a 7T system. Methods: Images were acquired from 35 neonates on 44 occasions (median age 39 + 6 postmenstrual weeks, range 33 + 4 to 52 + 6; median body weight 2.93 kg, range 1.57 to 5.3 kg) over a median time of 49 mins 30 s. Peripheral body temperature and physiological measures were recorded throughout scanning. Acquired sequences included T2 weighted (TSE), Actual Flip angle Imaging (AFI), functional MRI (BOLD EPI), susceptibility weighted imaging (SWI), and MR spectroscopy (STEAM). Results: There was no significant difference between temperature before and after scanning (p = 0.76) and image quality assessment compared favorably to state-of-the-art 3T acquisitions. Anatomical imaging demonstrated excellent sensitivity to structures which are typically hard to visualize at lower field strengths including the hippocampus, cerebellum, and vasculature. Images were also acquired with contrast mechanisms which are enhanced at ultra-high field including susceptibility weighted imaging, functional MRI, and MR spectroscopy. Discussion: We demonstrate safety and feasibility of imaging vulnerable neonates at ultra-high field and highlight the untapped potential for providing important new insights into brain development and pathological processes during this critical phase of early life.

Original language	English
Article number	1327075
Journal	Frontiers in Radiology
Volume	3
DOIs	https://doi.org/10.3389/fradi.2023.1327075
Publication status	Published - 2023

Keywords

brain
infant
magnetic resonance imaging (MRI)
neonate
neuroradiology
ultra-high field MRI

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10.3389/fradi.2023.1327075

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Bridgen, P., Tomi-Tricot, R., Uus, A., Cromb, D., Quirke, M., Almalbis, J., Bonse, B., De la Fuente Botella, M., Maggioni, A., Cio, P. D., Cawley, P., Casella, C., Dokumaci, A. S., Thomson, A. R., Willers Moore, J., Bridglal, D., Saravia, J., Finck, T., Price, A. N., ... Arichi, T. (2023). High resolution and contrast 7 tesla MR brain imaging of the neonate. Frontiers in Radiology, 3, Article 1327075. https://doi.org/10.3389/fradi.2023.1327075

@article{f23bd38437af47379d370f51cd10d588,

title = "High resolution and contrast 7 tesla MR brain imaging of the neonate",

abstract = "Introduction: Ultra-high field MR imaging offers marked gains in signal-to-noise ratio, spatial resolution, and contrast which translate to improved pathological and anatomical sensitivity. These benefits are particularly relevant for the neonatal brain which is rapidly developing and sensitive to injury. However, experience of imaging neonates at 7T has been limited due to regulatory, safety, and practical considerations. We aimed to establish a program for safely acquiring high resolution and contrast brain images from neonates on a 7T system. Methods: Images were acquired from 35 neonates on 44 occasions (median age 39 + 6 postmenstrual weeks, range 33 + 4 to 52 + 6; median body weight 2.93 kg, range 1.57 to 5.3 kg) over a median time of 49 mins 30 s. Peripheral body temperature and physiological measures were recorded throughout scanning. Acquired sequences included T2 weighted (TSE), Actual Flip angle Imaging (AFI), functional MRI (BOLD EPI), susceptibility weighted imaging (SWI), and MR spectroscopy (STEAM). Results: There was no significant difference between temperature before and after scanning (p = 0.76) and image quality assessment compared favorably to state-of-the-art 3T acquisitions. Anatomical imaging demonstrated excellent sensitivity to structures which are typically hard to visualize at lower field strengths including the hippocampus, cerebellum, and vasculature. Images were also acquired with contrast mechanisms which are enhanced at ultra-high field including susceptibility weighted imaging, functional MRI, and MR spectroscopy. Discussion: We demonstrate safety and feasibility of imaging vulnerable neonates at ultra-high field and highlight the untapped potential for providing important new insights into brain development and pathological processes during this critical phase of early life.",

keywords = "brain, infant, magnetic resonance imaging (MRI), neonate, neuroradiology, ultra-high field MRI",

author = "Philippa Bridgen and Raphael Tomi-Tricot and Alena Uus and Daniel Cromb and Megan Quirke and Jennifer Almalbis and Beya Bonse and {De la Fuente Botella}, Miguel and Alessandra Maggioni and Cio, {Pierluigi Di} and Paul Cawley and Chiara Casella and Dokumaci, {Ayse Sila} and Thomson, {Alice R.} and {Willers Moore}, Jucha and Devi Bridglal and Joao Saravia and Thomas Finck and Price, {Anthony N.} and Elisabeth Pickles and Lucilio Cordero-Grande and Alexia Egloff and Jonathan O{\textquoteright}Muircheartaigh and Counsell, {Serena J.} and Giles, {Sharon L.} and Maria Deprez and {De Vita}, Enrico and Rutherford, {Mary A.} and Edwards, {A. David} and Hajnal, {Joseph V.} and Malik, {Shaihan J.} and Tomoki Arichi",

note = "Publisher Copyright: 2024 Bridgen, Tomi-Tricot, Uus, Cromb, Quirke, Almalbis, Bonse, De la Fuente Botella, Maggioni, Cio, Cawley, Casella, Dokumaci, Thomson, Willers Moore, Bridglal, Saravia, Finck, Price, Pickles, Cordero-Grande, Egloff, O'Muircheartaigh, Counsell, Giles, Deprez, De Vita, Rutherford, Edwards, Hajnal, Malik and Arichi.",

year = "2023",

doi = "10.3389/fradi.2023.1327075",

language = "English",

volume = "3",

journal = "Frontiers in Radiology",

issn = "2673-8740",

publisher = "Frontiers Media",

}

Bridgen, P, Tomi-Tricot, R, Uus, A, Cromb, D, Quirke, M, Almalbis, J, Bonse, B, De la Fuente Botella, M, Maggioni, A, Cio, PD, Cawley, P , Casella, C, Dokumaci, AS, Thomson, AR, Willers Moore, J, Bridglal, D, Saravia, J, Finck, T, Price, AN, Pickles, E, Cordero-Grande, L , Egloff, A, O’Muircheartaigh, J, Counsell, SJ, Giles, SL, Deprez, M, De Vita, E, Rutherford, MA, Edwards, AD , Hajnal, JV , Malik, SJ & Arichi, T 2023, 'High resolution and contrast 7 tesla MR brain imaging of the neonate', Frontiers in Radiology, vol. 3, 1327075. https://doi.org/10.3389/fradi.2023.1327075

TY - JOUR

T1 - High resolution and contrast 7 tesla MR brain imaging of the neonate

AU - Bridgen, Philippa

AU - Tomi-Tricot, Raphael

AU - Uus, Alena

AU - Cromb, Daniel

AU - Quirke, Megan

AU - Almalbis, Jennifer

AU - Bonse, Beya

AU - De la Fuente Botella, Miguel

AU - Maggioni, Alessandra

AU - Cio, Pierluigi Di

AU - Cawley, Paul

AU - Casella, Chiara

AU - Dokumaci, Ayse Sila

AU - Thomson, Alice R.

AU - Willers Moore, Jucha

AU - Bridglal, Devi

AU - Saravia, Joao

AU - Finck, Thomas

AU - Price, Anthony N.

AU - Pickles, Elisabeth

AU - Cordero-Grande, Lucilio

AU - Egloff, Alexia

AU - O’Muircheartaigh, Jonathan

AU - Counsell, Serena J.

AU - Giles, Sharon L.

AU - Deprez, Maria

AU - De Vita, Enrico

AU - Rutherford, Mary A.

AU - Edwards, A. David

AU - Hajnal, Joseph V.

AU - Malik, Shaihan J.

AU - Arichi, Tomoki

N1 - Publisher Copyright: 2024 Bridgen, Tomi-Tricot, Uus, Cromb, Quirke, Almalbis, Bonse, De la Fuente Botella, Maggioni, Cio, Cawley, Casella, Dokumaci, Thomson, Willers Moore, Bridglal, Saravia, Finck, Price, Pickles, Cordero-Grande, Egloff, O'Muircheartaigh, Counsell, Giles, Deprez, De Vita, Rutherford, Edwards, Hajnal, Malik and Arichi.

PY - 2023

Y1 - 2023

N2 - Introduction: Ultra-high field MR imaging offers marked gains in signal-to-noise ratio, spatial resolution, and contrast which translate to improved pathological and anatomical sensitivity. These benefits are particularly relevant for the neonatal brain which is rapidly developing and sensitive to injury. However, experience of imaging neonates at 7T has been limited due to regulatory, safety, and practical considerations. We aimed to establish a program for safely acquiring high resolution and contrast brain images from neonates on a 7T system. Methods: Images were acquired from 35 neonates on 44 occasions (median age 39 + 6 postmenstrual weeks, range 33 + 4 to 52 + 6; median body weight 2.93 kg, range 1.57 to 5.3 kg) over a median time of 49 mins 30 s. Peripheral body temperature and physiological measures were recorded throughout scanning. Acquired sequences included T2 weighted (TSE), Actual Flip angle Imaging (AFI), functional MRI (BOLD EPI), susceptibility weighted imaging (SWI), and MR spectroscopy (STEAM). Results: There was no significant difference between temperature before and after scanning (p = 0.76) and image quality assessment compared favorably to state-of-the-art 3T acquisitions. Anatomical imaging demonstrated excellent sensitivity to structures which are typically hard to visualize at lower field strengths including the hippocampus, cerebellum, and vasculature. Images were also acquired with contrast mechanisms which are enhanced at ultra-high field including susceptibility weighted imaging, functional MRI, and MR spectroscopy. Discussion: We demonstrate safety and feasibility of imaging vulnerable neonates at ultra-high field and highlight the untapped potential for providing important new insights into brain development and pathological processes during this critical phase of early life.

AB - Introduction: Ultra-high field MR imaging offers marked gains in signal-to-noise ratio, spatial resolution, and contrast which translate to improved pathological and anatomical sensitivity. These benefits are particularly relevant for the neonatal brain which is rapidly developing and sensitive to injury. However, experience of imaging neonates at 7T has been limited due to regulatory, safety, and practical considerations. We aimed to establish a program for safely acquiring high resolution and contrast brain images from neonates on a 7T system. Methods: Images were acquired from 35 neonates on 44 occasions (median age 39 + 6 postmenstrual weeks, range 33 + 4 to 52 + 6; median body weight 2.93 kg, range 1.57 to 5.3 kg) over a median time of 49 mins 30 s. Peripheral body temperature and physiological measures were recorded throughout scanning. Acquired sequences included T2 weighted (TSE), Actual Flip angle Imaging (AFI), functional MRI (BOLD EPI), susceptibility weighted imaging (SWI), and MR spectroscopy (STEAM). Results: There was no significant difference between temperature before and after scanning (p = 0.76) and image quality assessment compared favorably to state-of-the-art 3T acquisitions. Anatomical imaging demonstrated excellent sensitivity to structures which are typically hard to visualize at lower field strengths including the hippocampus, cerebellum, and vasculature. Images were also acquired with contrast mechanisms which are enhanced at ultra-high field including susceptibility weighted imaging, functional MRI, and MR spectroscopy. Discussion: We demonstrate safety and feasibility of imaging vulnerable neonates at ultra-high field and highlight the untapped potential for providing important new insights into brain development and pathological processes during this critical phase of early life.

KW - brain

KW - infant

KW - magnetic resonance imaging (MRI)

KW - neonate

KW - neuroradiology

KW - ultra-high field MRI

UR - http://www.scopus.com/inward/record.url?scp=85183629272&partnerID=8YFLogxK

U2 - 10.3389/fradi.2023.1327075

DO - 10.3389/fradi.2023.1327075

M3 - Article

AN - SCOPUS:85183629272

SN - 2673-8740

VL - 3

JO - Frontiers in Radiology

JF - Frontiers in Radiology

M1 - 1327075

ER -

High resolution and contrast 7 tesla MR brain imaging of the neonate

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Keywords

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