High Resolution Three-Dimensional Cardiac Perfusion Imaging Using Compartment-Based k-t Principal Component Analysis

TY - JOUR

T1 - High Resolution Three-Dimensional Cardiac Perfusion Imaging Using Compartment-Based k-t Principal Component Analysis

AU - Vitanis, Viton

AU - Manka, Robert

AU - Giese, Daniel

AU - Pedersen, Henrik

AU - Plein, Sven

AU - Boesiger, Peter

AU - Kozerke, Sebastian

PY - 2011/2

Y1 - 2011/2

N2 - Three-dimensional myocardial perfusion imaging requires significant acceleration of data acquisition to achieve whole-heart coverage with adequate spatial and temporal resolution. The present article introduces a compartment-based k-t principal component analysis reconstruction approach, which permits three-dimensional perfusion imaging at 10-fold nominal acceleration. Using numerical simulations, it is shown that the compartment-based method results in accurate representations of dynamic signal intensity changes with significant improvements of temporal fidelity in comparison to conventional k-t principal component analysis reconstructions. Comparison of the two methods based on rest and stress three-dimensional perfusion data acquired with 2.3 x 2.3 x 10 mm(3) during a 225 msec acquisition window in patients confirms the findings and demonstrates the potential of compartment-based k-t principal component analysis for highly accelerated three-dimensional perfusion imaging.

AB - Three-dimensional myocardial perfusion imaging requires significant acceleration of data acquisition to achieve whole-heart coverage with adequate spatial and temporal resolution. The present article introduces a compartment-based k-t principal component analysis reconstruction approach, which permits three-dimensional perfusion imaging at 10-fold nominal acceleration. Using numerical simulations, it is shown that the compartment-based method results in accurate representations of dynamic signal intensity changes with significant improvements of temporal fidelity in comparison to conventional k-t principal component analysis reconstructions. Comparison of the two methods based on rest and stress three-dimensional perfusion data acquired with 2.3 x 2.3 x 10 mm(3) during a 225 msec acquisition window in patients confirms the findings and demonstrates the potential of compartment-based k-t principal component analysis for highly accelerated three-dimensional perfusion imaging.

U2 - 10.1002/mrm.22620

DO - 10.1002/mrm.22620

M3 - Article

SN - 1522-2594

VL - 65

SP - 575

EP - 587

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 2

ER -