High-speed photoacoustic-guided wavefront shaping for focusing light in scattering media

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
56 Downloads (Pure)


Wavefront shaping is becoming increasingly attractive as it promises to enable various biomedical applications by breaking through the optical diffusion limit that prevents light focusing at depths larger than ∼1 mm in biological tissue. However, despite recent advancements in wavefront shaping technology, such as those exploiting non-invasive photoacoustic-guidance, in vivo demonstrations remain challenging mainly due to rapid tissue speckle decorrelation. In this work, we report a high-speed photoacoustic-guided wavefront shaping method with a relatively simple experimental setup, based on the characterization of a scattering medium with a real-valued intensity transmission matrix. We demonstrated light focusing through an optical diffuser by optimizing 4096 binary amplitude modulation modes of a digital micromirror device within ∼300 ms, leading to a system runtime of 75 µs per input mode, which is 3 orders of magnitude smaller than the smallest runtime reported in literature so far using photoacoustic-guided wavefront shaping. Thus, our method is a solid step forward toward in vivo applications of wavefront shaping.

Original languageEnglish
Pages (from-to)1165-1168
Number of pages4
JournalOptics Letters
Issue number5
Publication statusPublished - 1 Mar 2021


Dive into the research topics of 'High-speed photoacoustic-guided wavefront shaping for focusing light in scattering media'. Together they form a unique fingerprint.

Cite this