High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo

Rhiannon Beard, Nisha Singh, Christophe Grundschober, Antony D. Gee, Edward W. Tate

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)
159 Downloads (Pure)

Abstract

A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.
Original languageEnglish
Pages (from-to)8120-8123
JournalCHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY
Volume54
Issue number58
Early online date5 Jul 2018
DOIs
Publication statusE-pub ahead of print - 5 Jul 2018

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