Abstract
A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.
Original language | English |
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Pages (from-to) | 8120-8123 |
Journal | CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY |
Volume | 54 |
Issue number | 58 |
Early online date | 5 Jul 2018 |
DOIs | |
Publication status | E-pub ahead of print - 5 Jul 2018 |