Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

Valeria Mondelli; Carmine M. Pariante; Serena Navari; Monica Aas; Alessandro D'Albenzio; Marta Di Forti; Rowena Handley; Nilay Hepgul; Tiago Reis Marques; Heather Taylor; Andrew S. Papadopoulos; Katherine J. Aitchison; Robin M. Murray; Paola Dazzan

doi:10.1016/j.schres.2009.12.021

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

Valeria Mondelli, Carmine M. Pariante, Serena Navari, Monica Aas, Alessandro D'Albenzio, Marta Di Forti, Rowena Handley, Nilay Hepgul, Tiago Reis Marques, Heather Taylor, Andrew S. Papadopoulos, Katherine J. Aitchison, Robin M. Murray, Paola Dazzan

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Abstract

This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.

Original language	English
Pages (from-to)	75 - 78
Number of pages	4
Journal	Schizophrenia Research
Volume	119
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2009.12.021
Publication status	Published - Jun 2010

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Mondelli, V., Pariante, C. M., Navari, S., Aas, M., D'Albenzio, A., Di Forti, M., Handley, R., Hepgul, N., Marques, T. R., Taylor, H., Papadopoulos, A. S., Aitchison, K. J., Murray, R. M., & Dazzan, P. (2010). Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis. Schizophrenia Research, 119(1-3), 75 - 78. https://doi.org/10.1016/j.schres.2009.12.021

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title = "Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis",

abstract = "This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.",

author = "Valeria Mondelli and Pariante, {Carmine M.} and Serena Navari and Monica Aas and Alessandro D'Albenzio and {Di Forti}, Marta and Rowena Handley and Nilay Hepgul and Marques, {Tiago Reis} and Heather Taylor and Papadopoulos, {Andrew S.} and Aitchison, {Katherine J.} and Murray, {Robin M.} and Paola Dazzan",

year = "2010",

month = jun,

doi = "10.1016/j.schres.2009.12.021",

language = "English",

volume = "119",

pages = "75 -- 78",

journal = "Schizophrenia Research",

issn = "1573-2509",

publisher = "Elsevier",

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}

Mondelli, V , Pariante, CM, Navari, S, Aas, M, D'Albenzio, A, Di Forti, M, Handley, R, Hepgul, N, Marques, TR, Taylor, H, Papadopoulos, AS, Aitchison, KJ , Murray, RM & Dazzan, P 2010, 'Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis', Schizophrenia Research, vol. 119, no. 1-3, pp. 75 - 78. https://doi.org/10.1016/j.schres.2009.12.021

TY - JOUR

T1 - Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

AU - Mondelli, Valeria

AU - Pariante, Carmine M.

AU - Navari, Serena

AU - Aas, Monica

AU - D'Albenzio, Alessandro

AU - Di Forti, Marta

AU - Handley, Rowena

AU - Hepgul, Nilay

AU - Marques, Tiago Reis

AU - Taylor, Heather

AU - Papadopoulos, Andrew S.

AU - Aitchison, Katherine J.

AU - Murray, Robin M.

AU - Dazzan, Paola

PY - 2010/6

Y1 - 2010/6

N2 - This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.

AB - This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.

U2 - 10.1016/j.schres.2009.12.021

DO - 10.1016/j.schres.2009.12.021

M3 - Article

SN - 1573-2509

VL - 119

SP - 75

EP - 78

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

Abstract

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