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Higher levels of objectively measured sedentary behavior is associated with worse cognitive ability: Two-year follow-up study in community-dwelling older adults

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Po-Wen Ku, Yi-Te Liu, Ming-Kuei Lo, Li-Jung Chen, Brendon Stubbs

Original languageEnglish
JournalExperimental Gerontology
Early online date28 Sep 2017
DOIs
Publication statusE-pub ahead of print - 28 Sep 2017

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Abstract

AbstractBackground A number of cross-sectional studies have suggested that higher levels of sedentary (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objective SB. This study investigates the relationship between objective SB and future cognitive abilities in a cohort of older adults. Methods A longitudinal study over 22.12 ± 1.46 months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7 days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. Results 274 community-dwelling older adults finished the study (age = 74.6 ± 6.2, % female = 54.4%). At baseline, 20.1% (n = 55), 48.5% (n = 133) and 31.4% (n = 86) of the sample engaged in high (> 11 h), medium (8–10.99) and low (< 8 h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00–1.19), with the strongest relationship evident in those engaging in over 11 h of SB (ARR 2.27 (1.24–4.16). The relationship remained evident after adjusting for depressive symptoms and physical activity. Conclusion Our data suggests that objective SB, particularly when over 11 h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.

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