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Higher order spherical harmonics reconstruction of fetal diffusion MRI with intensity correction

Research output: Contribution to journalArticle

Original languageEnglish
JournalIeee Transactions on Medical Imaging
DOIs
Publication statusPublished - 22 Sep 2019

Documents

  • DeprezTMI2019

    DeprezTMI2019.pdf, 4.37 MB, application/pdf

    23/09/2019

    Accepted author manuscript

King's Authors

Abstract

We present a novel method for higher order reconstruction of fetal diffusion MRI signal that enables detection of fiber crossings. We combine data-driven motion and intensity correction with super-resolution reconstruction and spherical harmonic parametrisation to reconstruct data scattered in both spatial and angular domains into consistent fetal dMRI signal suitable for further diffusion analysis. We show that intensity correction is essential for good performance of the method and identify anatomically plausible fiber crossings. The proposed methodology has potential to facilitate detailed investigation of developing brain connectivity and microstructure in-utero.

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