Highly efficient image navigator based 3D whole-heart cardiac MRA at 0.55T

Carlos Castillo-Passi; Karl P Kunze; Michael G Crabb; Camila Munoz; Anastasia Fotaki; Radhouene Neji; Pablo Irarrazaval; Claudia Prieto; René M Botnar

doi:10.1002/mrm.30316

Highly efficient image navigator based 3D whole-heart cardiac MRA at 0.55T

Carlos Castillo-Passi, Karl P Kunze, Michael G Crabb, Camila Munoz, Anastasia Fotaki, Radhouene Neji, Pablo Irarrazaval, Claudia Prieto, René M Botnar

Biomedical Engineering Department

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Abstract

Purpose: To develop and evaluate a highly efficient free-breathing and contrast-agent-free three-dimensional (3D) whole-heart Cardiac Magnetic Resonance Angiography (CMRA) sequence at 0.55T. Methods: Free-breathing whole-heart CMRA has been previously proposed at 1.5 and 3T. Direct application of this sequence to 0.55T is not possible due to changes in the magnetic properties of the tissues. To enable free-breathing CMRA at 0.55T, pulse sequence design and acquisition parameters of a previously proposed whole-heart CMRA framework are optimized via Bloch simulations. Image navigators (iNAVs) are used to enable nonrigid respiratory motion-correction and 100% respiratory scan efficiency. Patch-based low-rank denoising is employed to accelerate the scan and account for the reduced signal-to-noise ratio at 0.55T. The proposed approach was evaluated on 11 healthy subjects. Image quality was assessed by a clinical expert (1: poor to 5: excellent) for all intrapericardiac structures. Quantitative evaluation was performed by assessing the vessel sharpness of the proximal right coronary artery (RCA). Results: Optimization resulted in an imaging flip angle of (Formula presented.), fat saturation flip angle of (Formula presented.), and six k-space lines for iNAV encoding. The relevant cardiac structures and main coronary arteries were visible in all subjects, with excellent image quality (mean (Formula presented.)) and minimal artifacts (mean (Formula presented.)), with RCA vessel sharpness ((Formula presented.)) comparable to previous studies at 1.5T. Conclusion: The proposed approach enables 3D whole-heart CMRA at 0.55T in a 6-min scan ((Formula presented.)), providing excellent image quality, minimal artifacts, and comparable vessel sharpness to previous 1.5T studies. Future work will include the evaluation of the proposed approach in patients with cardiovascular disease.

Original language	English
Pages (from-to)	689-698
Number of pages	10
Journal	Magnetic Resonance in Medicine
Volume	93
Issue number	2
DOIs	https://doi.org/10.1002/mrm.30316
Publication status	Published - Feb 2025

Keywords

Humans
Magnetic Resonance Angiography/methods
Imaging, Three-Dimensional/methods
Heart/diagnostic imaging
Male
Adult
Algorithms
Female
Coronary Vessels/diagnostic imaging
Signal-To-Noise Ratio
Image Processing, Computer-Assisted/methods
Reproducibility of Results
Image Interpretation, Computer-Assisted/methods
Image Enhancement/methods

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mrm.30316

Magnetic Resonance in Med - 2024 - Castillo‐Passi - Highly efficient image navigator based 3D whole‐heart cardiac MRA at 0Final published version, 3.03 MB

Cite this

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title = "Highly efficient image navigator based 3D whole-heart cardiac MRA at 0.55T",

abstract = "Purpose: To develop and evaluate a highly efficient free-breathing and contrast-agent-free three-dimensional (3D) whole-heart Cardiac Magnetic Resonance Angiography (CMRA) sequence at 0.55T. Methods: Free-breathing whole-heart CMRA has been previously proposed at 1.5 and 3T. Direct application of this sequence to 0.55T is not possible due to changes in the magnetic properties of the tissues. To enable free-breathing CMRA at 0.55T, pulse sequence design and acquisition parameters of a previously proposed whole-heart CMRA framework are optimized via Bloch simulations. Image navigators (iNAVs) are used to enable nonrigid respiratory motion-correction and 100% respiratory scan efficiency. Patch-based low-rank denoising is employed to accelerate the scan and account for the reduced signal-to-noise ratio at 0.55T. The proposed approach was evaluated on 11 healthy subjects. Image quality was assessed by a clinical expert (1: poor to 5: excellent) for all intrapericardiac structures. Quantitative evaluation was performed by assessing the vessel sharpness of the proximal right coronary artery (RCA). Results: Optimization resulted in an imaging flip angle of (Formula presented.), fat saturation flip angle of (Formula presented.), and six k-space lines for iNAV encoding. The relevant cardiac structures and main coronary arteries were visible in all subjects, with excellent image quality (mean (Formula presented.)) and minimal artifacts (mean (Formula presented.)), with RCA vessel sharpness ((Formula presented.)) comparable to previous studies at 1.5T. Conclusion: The proposed approach enables 3D whole-heart CMRA at 0.55T in a 6-min scan ((Formula presented.)), providing excellent image quality, minimal artifacts, and comparable vessel sharpness to previous 1.5T studies. Future work will include the evaluation of the proposed approach in patients with cardiovascular disease.",

keywords = "Humans, Magnetic Resonance Angiography/methods, Imaging, Three-Dimensional/methods, Heart/diagnostic imaging, Male, Adult, Algorithms, Female, Coronary Vessels/diagnostic imaging, Signal-To-Noise Ratio, Image Processing, Computer-Assisted/methods, Reproducibility of Results, Image Interpretation, Computer-Assisted/methods, Image Enhancement/methods",

author = "Carlos Castillo-Passi and Kunze, {Karl P} and Crabb, {Michael G} and Camila Munoz and Anastasia Fotaki and Radhouene Neji and Pablo Irarrazaval and Claudia Prieto and Botnar, {Ren{\'e} M}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.",

year = "2025",

month = feb,

doi = "10.1002/mrm.30316",

language = "English",

volume = "93",

pages = "689--698",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "WILEY-BLACKWELL",

number = "2",

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T1 - Highly efficient image navigator based 3D whole-heart cardiac MRA at 0.55T

AU - Castillo-Passi, Carlos

AU - Kunze, Karl P

AU - Crabb, Michael G

AU - Munoz, Camila

AU - Fotaki, Anastasia

AU - Neji, Radhouene

AU - Irarrazaval, Pablo

AU - Prieto, Claudia

AU - Botnar, René M

PY - 2025/2

Y1 - 2025/2

N2 - Purpose: To develop and evaluate a highly efficient free-breathing and contrast-agent-free three-dimensional (3D) whole-heart Cardiac Magnetic Resonance Angiography (CMRA) sequence at 0.55T. Methods: Free-breathing whole-heart CMRA has been previously proposed at 1.5 and 3T. Direct application of this sequence to 0.55T is not possible due to changes in the magnetic properties of the tissues. To enable free-breathing CMRA at 0.55T, pulse sequence design and acquisition parameters of a previously proposed whole-heart CMRA framework are optimized via Bloch simulations. Image navigators (iNAVs) are used to enable nonrigid respiratory motion-correction and 100% respiratory scan efficiency. Patch-based low-rank denoising is employed to accelerate the scan and account for the reduced signal-to-noise ratio at 0.55T. The proposed approach was evaluated on 11 healthy subjects. Image quality was assessed by a clinical expert (1: poor to 5: excellent) for all intrapericardiac structures. Quantitative evaluation was performed by assessing the vessel sharpness of the proximal right coronary artery (RCA). Results: Optimization resulted in an imaging flip angle of (Formula presented.), fat saturation flip angle of (Formula presented.), and six k-space lines for iNAV encoding. The relevant cardiac structures and main coronary arteries were visible in all subjects, with excellent image quality (mean (Formula presented.)) and minimal artifacts (mean (Formula presented.)), with RCA vessel sharpness ((Formula presented.)) comparable to previous studies at 1.5T. Conclusion: The proposed approach enables 3D whole-heart CMRA at 0.55T in a 6-min scan ((Formula presented.)), providing excellent image quality, minimal artifacts, and comparable vessel sharpness to previous 1.5T studies. Future work will include the evaluation of the proposed approach in patients with cardiovascular disease.

AB - Purpose: To develop and evaluate a highly efficient free-breathing and contrast-agent-free three-dimensional (3D) whole-heart Cardiac Magnetic Resonance Angiography (CMRA) sequence at 0.55T. Methods: Free-breathing whole-heart CMRA has been previously proposed at 1.5 and 3T. Direct application of this sequence to 0.55T is not possible due to changes in the magnetic properties of the tissues. To enable free-breathing CMRA at 0.55T, pulse sequence design and acquisition parameters of a previously proposed whole-heart CMRA framework are optimized via Bloch simulations. Image navigators (iNAVs) are used to enable nonrigid respiratory motion-correction and 100% respiratory scan efficiency. Patch-based low-rank denoising is employed to accelerate the scan and account for the reduced signal-to-noise ratio at 0.55T. The proposed approach was evaluated on 11 healthy subjects. Image quality was assessed by a clinical expert (1: poor to 5: excellent) for all intrapericardiac structures. Quantitative evaluation was performed by assessing the vessel sharpness of the proximal right coronary artery (RCA). Results: Optimization resulted in an imaging flip angle of (Formula presented.), fat saturation flip angle of (Formula presented.), and six k-space lines for iNAV encoding. The relevant cardiac structures and main coronary arteries were visible in all subjects, with excellent image quality (mean (Formula presented.)) and minimal artifacts (mean (Formula presented.)), with RCA vessel sharpness ((Formula presented.)) comparable to previous studies at 1.5T. Conclusion: The proposed approach enables 3D whole-heart CMRA at 0.55T in a 6-min scan ((Formula presented.)), providing excellent image quality, minimal artifacts, and comparable vessel sharpness to previous 1.5T studies. Future work will include the evaluation of the proposed approach in patients with cardiovascular disease.

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KW - Magnetic Resonance Angiography/methods

KW - Imaging, Three-Dimensional/methods

KW - Heart/diagnostic imaging

KW - Male

KW - Adult

KW - Algorithms

KW - Female

KW - Coronary Vessels/diagnostic imaging

KW - Signal-To-Noise Ratio

KW - Image Processing, Computer-Assisted/methods

KW - Reproducibility of Results

KW - Image Interpretation, Computer-Assisted/methods

KW - Image Enhancement/methods

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U2 - 10.1002/mrm.30316

DO - 10.1002/mrm.30316

M3 - Article

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SN - 0740-3194

VL - 93

SP - 689

EP - 698

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 2

ER -

Highly efficient image navigator based 3D whole-heart cardiac MRA at 0.55T

Abstract

Keywords

UN SDGs

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