Hipoactivación precúnea e insular durante el procesamiento cognitivo en el primer episodio psicótico: revisión sistemática y metaanálisis de estudios de fMRI

Pau Soldevila-Matías; Anton Albajes-Eizagirre; Joaquim Radua; Gracián García-Martí; José M. Rubio; Diana Tordesillas-Gutierrez; Inmaculada Fuentes-Durá; Aleix Solanes; Lydia Fortea; Dominic Oliver; Julio Sanjuán

doi:10.1016/j.rpsm.2020.08.001

Hipoactivación precúnea e insular durante el procesamiento cognitivo en el primer episodio psicótico: revisión sistemática y metaanálisis de estudios de fMRI

Translated title of the contribution: Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies

Pau Soldevila-Matías, Anton Albajes-Eizagirre, Joaquim Radua^*, Gracián García-Martí, José M. Rubio, Diana Tordesillas-Gutierrez, Inmaculada Fuentes-Durá, Aleix Solanes, Lydia Fortea, Dominic Oliver, Julio Sanjuán

^*Corresponding author for this work

Psychosis Studies

Research output: Contribution to journal › Review article › peer-review

Abstract

Introduction: The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP. Methods: Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines. Results: Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum. Conclusions: While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.

Translated title of the contribution	Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies
Original language	Spanish
Journal	Revista de Psiquiatria y Salud Mental
DOIs	https://doi.org/10.1016/j.rpsm.2020.08.001
Publication status	Accepted/In press - 1 Jan 2020

Keywords

Cognitive tasks
First-episode psychosis
Frontal lobe
Functional MRI
Insula

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.rpsm.2020.08.001

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Soldevila-Matías, P., Albajes-Eizagirre, A., Radua, J., García-Martí, G., Rubio, J. M., Tordesillas-Gutierrez, D., Fuentes-Durá, I., Solanes, A., Fortea, L., Oliver, D., & Sanjuán, J. (Accepted/In press). Hipoactivación precúnea e insular durante el procesamiento cognitivo en el primer episodio psicótico: revisión sistemática y metaanálisis de estudios de fMRI. Revista de Psiquiatria y Salud Mental. https://doi.org/10.1016/j.rpsm.2020.08.001

@article{78efddaf412142ab989120b9e654bd93,

title = "Hipoactivaci{\'o}n prec{\'u}nea e insular durante el procesamiento cognitivo en el primer episodio psic{\'o}tico: revisi{\'o}n sistem{\'a}tica y metaan{\'a}lisis de estudios de fMRI",

abstract = "Introduction: The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP. Methods: Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines. Results: Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum. Conclusions: While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.",

keywords = "Cognitive tasks, First-episode psychosis, Frontal lobe, Functional MRI, Insula",

author = "Pau Soldevila-Mat{\'i}as and Anton Albajes-Eizagirre and Joaquim Radua and Graci{\'a}n Garc{\'i}a-Mart{\'i} and Rubio, {Jos{\'e} M.} and Diana Tordesillas-Gutierrez and Inmaculada Fuentes-Dur{\'a} and Aleix Solanes and Lydia Fortea and Dominic Oliver and Julio Sanju{\'a}n",

year = "2020",

month = jan,

day = "1",

doi = "10.1016/j.rpsm.2020.08.001",

language = "Spanish",

journal = "Revista de Psiquiatr??a y Salud Mental",

issn = "1888-9891",

publisher = "Ediciones Doyma, S.L.",

}

Soldevila-Matías, P, Albajes-Eizagirre, A, Radua, J, García-Martí, G, Rubio, JM, Tordesillas-Gutierrez, D, Fuentes-Durá, I, Solanes, A, Fortea, L, Oliver, D & Sanjuán, J 2020, 'Hipoactivación precúnea e insular durante el procesamiento cognitivo en el primer episodio psicótico: revisión sistemática y metaanálisis de estudios de fMRI', Revista de Psiquiatria y Salud Mental. https://doi.org/10.1016/j.rpsm.2020.08.001

TY - JOUR

T1 - Hipoactivación precúnea e insular durante el procesamiento cognitivo en el primer episodio psicótico

T2 - revisión sistemática y metaanálisis de estudios de fMRI

AU - Soldevila-Matías, Pau

AU - Albajes-Eizagirre, Anton

AU - Radua, Joaquim

AU - García-Martí, Gracián

AU - Rubio, José M.

AU - Tordesillas-Gutierrez, Diana

AU - Fuentes-Durá, Inmaculada

AU - Solanes, Aleix

AU - Fortea, Lydia

AU - Oliver, Dominic

AU - Sanjuán, Julio

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Introduction: The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP. Methods: Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines. Results: Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum. Conclusions: While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.

AB - Introduction: The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP. Methods: Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines. Results: Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum. Conclusions: While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.

KW - Cognitive tasks

KW - First-episode psychosis

KW - Frontal lobe

KW - Functional MRI

KW - Insula

UR - http://www.scopus.com/inward/record.url?scp=85091849124&partnerID=8YFLogxK

U2 - 10.1016/j.rpsm.2020.08.001

DO - 10.1016/j.rpsm.2020.08.001

M3 - Review article

AN - SCOPUS:85091849124

SN - 1888-9891

JO - Revista de Psiquiatr??a y Salud Mental

JF - Revista de Psiquiatr??a y Salud Mental

ER -

Hipoactivación precúnea e insular durante el procesamiento cognitivo en el primer episodio psicótico: revisión sistemática y metaanálisis de estudios de fMRI

Abstract

Keywords

UN SDGs

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