Hippocampal atrophy in first episode depression: a meta-analysis of magnetic resonance imaging studies

James Cole; Sergi G Costafreda; Peter McGuffin; Cynthia H Y Fu

doi:10.1016/j.jad.2011.05.057

Hippocampal atrophy in first episode depression: a meta-analysis of magnetic resonance imaging studies

1Department of Hepatology, Imperial College London, London, UK. 2Institute of Liver Studies at King's College School of Medicine at King's College Hospital, London, UK. 3Institute of Human Health and Performance, University College London, London, UK. 4Department of Asthma Allergy and Lung Biology, King's College London, London, UK. 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada.

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Reduced hippocampal volume has been consistently observed in major depressive disorder. Hippocampal volume loss is particularly evident in patients with recurrent and chronic depression. However, the reports in first episode depression have been mixed.

METHODS: We performed a random effects meta-analysis to establish whether hippocampal atrophy exists from disease onset. We included magnetic resonance imaging studies of hippocampal volume in patients with first episode major depressive disorder and matched healthy controls.

RESULTS: A total of 7 studies met our inclusion and exclusion criteria, representing independent observations in a total sample of 191 patients and 282 healthy controls. The cumulative analysis revealed hippocampal volume loss in patients with first episode depression relative to controls in both the left (standardised mean difference, SMD = -0.41, 95% Confidence Interval: [-0.78;-0.03], z = -2.14, p = 0.0321) and right (SMD = -0.53[-0.98;-0.09], z = -2.38, p = 0.0173) hippocampi. The average volume reduction was -4.0% in the left and -4.5% in the right hippocampus.

CONCLUSIONS: Hippocampal volume loss in first episode depression is consistent with a neurodevelopmental model of depression, advocating hippocampal structure as a potential diagnostic neurobiomarker for depression.

Original language	English
Pages (from-to)	483-7
Number of pages	5
Journal	Journal of Affective Disorders
Volume	134
Issue number	1-3
DOIs	https://doi.org/10.1016/j.jad.2011.05.057
Publication status	Published - Nov 2011

Keywords

Atrophy/pathology
Biomarkers
Case-Control Studies
Depression
Depressive Disorder/pathology
Depressive Disorder, Major/pathology
Hippocampus/pathology
Humans
Magnetic Resonance Imaging/methods
Magnetics

Access to Document

10.1016/j.jad.2011.05.057

Cite this

@article{b5aff8e02f354e0588ca8da83f8cec2d,

title = "Hippocampal atrophy in first episode depression: a meta-analysis of magnetic resonance imaging studies",

abstract = "BACKGROUND: Reduced hippocampal volume has been consistently observed in major depressive disorder. Hippocampal volume loss is particularly evident in patients with recurrent and chronic depression. However, the reports in first episode depression have been mixed.METHODS: We performed a random effects meta-analysis to establish whether hippocampal atrophy exists from disease onset. We included magnetic resonance imaging studies of hippocampal volume in patients with first episode major depressive disorder and matched healthy controls.RESULTS: A total of 7 studies met our inclusion and exclusion criteria, representing independent observations in a total sample of 191 patients and 282 healthy controls. The cumulative analysis revealed hippocampal volume loss in patients with first episode depression relative to controls in both the left (standardised mean difference, SMD = -0.41, 95\% Confidence Interval: [-0.78;-0.03], z = -2.14, p = 0.0321) and right (SMD = -0.53[-0.98;-0.09], z = -2.38, p = 0.0173) hippocampi. The average volume reduction was -4.0\% in the left and -4.5\% in the right hippocampus.CONCLUSIONS: Hippocampal volume loss in first episode depression is consistent with a neurodevelopmental model of depression, advocating hippocampal structure as a potential diagnostic neurobiomarker for depression.",

keywords = "Atrophy/pathology, Biomarkers, Case-Control Studies, Depression, Depressive Disorder/pathology, Depressive Disorder, Major/pathology, Hippocampus/pathology, Humans, Magnetic Resonance Imaging/methods, Magnetics",

author = "James Cole and Costafreda, \{Sergi G\} and Peter McGuffin and Fu, \{Cynthia H Y\}",

year = "2011",

month = nov,

doi = "10.1016/j.jad.2011.05.057",

language = "English",

volume = "134",

pages = "483--7",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Hippocampal atrophy in first episode depression

T2 - a meta-analysis of magnetic resonance imaging studies

AU - Cole, James

AU - Costafreda, Sergi G

AU - McGuffin, Peter

AU - Fu, Cynthia H Y

PY - 2011/11

Y1 - 2011/11

N2 - BACKGROUND: Reduced hippocampal volume has been consistently observed in major depressive disorder. Hippocampal volume loss is particularly evident in patients with recurrent and chronic depression. However, the reports in first episode depression have been mixed.METHODS: We performed a random effects meta-analysis to establish whether hippocampal atrophy exists from disease onset. We included magnetic resonance imaging studies of hippocampal volume in patients with first episode major depressive disorder and matched healthy controls.RESULTS: A total of 7 studies met our inclusion and exclusion criteria, representing independent observations in a total sample of 191 patients and 282 healthy controls. The cumulative analysis revealed hippocampal volume loss in patients with first episode depression relative to controls in both the left (standardised mean difference, SMD = -0.41, 95% Confidence Interval: [-0.78;-0.03], z = -2.14, p = 0.0321) and right (SMD = -0.53[-0.98;-0.09], z = -2.38, p = 0.0173) hippocampi. The average volume reduction was -4.0% in the left and -4.5% in the right hippocampus.CONCLUSIONS: Hippocampal volume loss in first episode depression is consistent with a neurodevelopmental model of depression, advocating hippocampal structure as a potential diagnostic neurobiomarker for depression.

AB - BACKGROUND: Reduced hippocampal volume has been consistently observed in major depressive disorder. Hippocampal volume loss is particularly evident in patients with recurrent and chronic depression. However, the reports in first episode depression have been mixed.METHODS: We performed a random effects meta-analysis to establish whether hippocampal atrophy exists from disease onset. We included magnetic resonance imaging studies of hippocampal volume in patients with first episode major depressive disorder and matched healthy controls.RESULTS: A total of 7 studies met our inclusion and exclusion criteria, representing independent observations in a total sample of 191 patients and 282 healthy controls. The cumulative analysis revealed hippocampal volume loss in patients with first episode depression relative to controls in both the left (standardised mean difference, SMD = -0.41, 95% Confidence Interval: [-0.78;-0.03], z = -2.14, p = 0.0321) and right (SMD = -0.53[-0.98;-0.09], z = -2.38, p = 0.0173) hippocampi. The average volume reduction was -4.0% in the left and -4.5% in the right hippocampus.CONCLUSIONS: Hippocampal volume loss in first episode depression is consistent with a neurodevelopmental model of depression, advocating hippocampal structure as a potential diagnostic neurobiomarker for depression.

KW - Atrophy/pathology

KW - Biomarkers

KW - Case-Control Studies

KW - Depression

KW - Depressive Disorder/pathology

KW - Depressive Disorder, Major/pathology

KW - Hippocampus/pathology

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Magnetics

U2 - 10.1016/j.jad.2011.05.057

DO - 10.1016/j.jad.2011.05.057

M3 - Article

C2 - 21745692

SN - 0165-0327

VL - 134

SP - 483

EP - 487

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 1-3

ER -

Hippocampal atrophy in first episode depression: a meta-analysis of magnetic resonance imaging studies

Abstract

Keywords

Access to Document

Fingerprint

Cite this