Hippocampal Neurogenesis in Alzheimer's Disease: Is There a Role for Dietary Modulation?

Aleksandra Maruszak; Adam Pilarski; Tytus Murphy; Nicholas Branch; Sandrine Thuret

doi:10.3233/JAD-131004

Hippocampal Neurogenesis in Alzheimer's Disease: Is There a Role for Dietary Modulation?

Aleksandra Maruszak, Adam Pilarski, Tytus Murphy, Nicholas Branch, Sandrine Thuret^*

^*Corresponding author for this work

King's College London

Research output: Contribution to journal › Literature review › peer-review

57 Citations (Scopus)

Abstract

Alterations in hippocampal neurogenesis have been recognized as an integral part of Alzheimer's disease. Adult hippocampal neurogenesis is regulated by intrinsic and extrinsic factors; one of them is diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis studies in Alzheimer's disease and focuses on the role of diet. The review highlights some of the key dietary compounds and interventions such as calorie restriction, fat, polyphenols, zinc, folate, alcohol and thiamine, and emphasizes the pathways that they modify.

Original language	English
Article number	N/A
Pages (from-to)	11-38
Number of pages	28
Journal	JOURNAL OF ALZHEIMERS DISEASE
Volume	38
Issue number	1
Early online date	2 Aug 2013
DOIs	https://doi.org/10.3233/JAD-131004
Publication status	Published - 2014

Keywords

Alzheimer's disease
calorie restriction
diet
fatty acids
folate
neurogenesis
nutrients
polyphenols
thiamine
zinc
TRANSGENIC MOUSE MODEL
POLYUNSATURATED FATTY-ACIDS
NEURAL PROGENITOR CELLS
FOREBRAIN-SPECIFIC PRESENILIN-1
IMPAIRED ADULT NEUROGENESIS
PLACEBO-CONTROLLED TRIAL
BETA-AMYLOID PRODUCTION
GINKGO-BILOBA EXTRACT
B-VITAMIN TREATMENT
FACTOR G-CSF

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title = "Hippocampal Neurogenesis in Alzheimer's Disease: Is There a Role for Dietary Modulation?",

abstract = "Alterations in hippocampal neurogenesis have been recognized as an integral part of Alzheimer's disease. Adult hippocampal neurogenesis is regulated by intrinsic and extrinsic factors; one of them is diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis studies in Alzheimer's disease and focuses on the role of diet. The review highlights some of the key dietary compounds and interventions such as calorie restriction, fat, polyphenols, zinc, folate, alcohol and thiamine, and emphasizes the pathways that they modify.",

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author = "Aleksandra Maruszak and Adam Pilarski and Tytus Murphy and Nicholas Branch and Sandrine Thuret",

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AU - Pilarski, Adam

AU - Murphy, Tytus

AU - Branch, Nicholas

AU - Thuret, Sandrine

PY - 2014

Y1 - 2014

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AB - Alterations in hippocampal neurogenesis have been recognized as an integral part of Alzheimer's disease. Adult hippocampal neurogenesis is regulated by intrinsic and extrinsic factors; one of them is diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis studies in Alzheimer's disease and focuses on the role of diet. The review highlights some of the key dietary compounds and interventions such as calorie restriction, fat, polyphenols, zinc, folate, alcohol and thiamine, and emphasizes the pathways that they modify.

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KW - calorie restriction

KW - diet

KW - fatty acids

KW - folate

KW - neurogenesis

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KW - zinc

KW - TRANSGENIC MOUSE MODEL

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KW - PLACEBO-CONTROLLED TRIAL

KW - BETA-AMYLOID PRODUCTION

KW - GINKGO-BILOBA EXTRACT

KW - B-VITAMIN TREATMENT

KW - FACTOR G-CSF

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DO - 10.3233/JAD-131004

M3 - Literature review

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Hippocampal Neurogenesis in Alzheimer's Disease: Is There a Role for Dietary Modulation?

Abstract

Keywords

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