Hippocampal Neurogenesis in Alzheimer's Disease: Is There a Role for Dietary Modulation?

Aleksandra Maruszak, Adam Pilarski, Tytus Murphy, Nicholas Branch, Sandrine Thuret*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

55 Citations (Scopus)

Abstract

Alterations in hippocampal neurogenesis have been recognized as an integral part of Alzheimer's disease. Adult hippocampal neurogenesis is regulated by intrinsic and extrinsic factors; one of them is diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis studies in Alzheimer's disease and focuses on the role of diet. The review highlights some of the key dietary compounds and interventions such as calorie restriction, fat, polyphenols, zinc, folate, alcohol and thiamine, and emphasizes the pathways that they modify.

Original languageEnglish
Article numberN/A
Pages (from-to)11-38
Number of pages28
JournalJOURNAL OF ALZHEIMERS DISEASE
Volume38
Issue number1
Early online date2 Aug 2013
DOIs
Publication statusPublished - 2014

Keywords

  • Alzheimer's disease
  • calorie restriction
  • diet
  • fatty acids
  • folate
  • neurogenesis
  • nutrients
  • polyphenols
  • thiamine
  • zinc
  • TRANSGENIC MOUSE MODEL
  • POLYUNSATURATED FATTY-ACIDS
  • NEURAL PROGENITOR CELLS
  • FOREBRAIN-SPECIFIC PRESENILIN-1
  • IMPAIRED ADULT NEUROGENESIS
  • PLACEBO-CONTROLLED TRIAL
  • BETA-AMYLOID PRODUCTION
  • GINKGO-BILOBA EXTRACT
  • B-VITAMIN TREATMENT
  • FACTOR G-CSF

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