Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults

Sara Cipriani; Isidre Ferrer; Eleonora Aronica; Gabor G Kovacs; Catherine Verney; Jeannette Nardelli; Suonavy Khung; Anne-Lise Delezoide; Ivan Milenkovic; Sowmyalakshmi Rasika; Philippe Manivet; Jean-Louis Benifla; Nicolas Deriot; Pierre Gressens; Homa Adle-Biassette

doi:10.1093/cercor/bhy096

Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults

Sara Cipriani, Isidre Ferrer, Eleonora Aronica, Gabor G Kovacs, Catherine Verney, Jeannette Nardelli, Suonavy Khung, Anne-Lise Delezoide, Ivan Milenkovic, Sowmyalakshmi Rasika, Philippe Manivet, Jean-Louis Benifla, Nicolas Deriot, Pierre Gressens, Homa Adle-Biassette

University of Paris VII - Denis Diderot University
Department of Pathology and Experimental Therapeutics, University of Barcelona, Bellvitge Campus, L'Hospitalet de Llobregat, Spain; Centre for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Institute Carlos III, Madrid, Spain.
Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Medical University of Vienna
APHP, Service de Biologie du Développement, Hôpital Robert-Debré, APHP, Paris, France.
APHP, Plateforme de Bio-Pathologie et de Technologies Innovantes en Santé, Centre de Ressources Biologiques BB-0033-00064, Hôpital Lariboisière, Paris, France.
APHP, Service de Gynécologie-Obstétrique, Hôpital Lariboisère, 75010 Paris, France.
Service d'Anatomie et de Cytologie Pathologiques, Hôpital Lariboisère, 75010 Paris, France.

Research output: Contribution to journal › Article › peer-review

120 Citations (Scopus)

128 Downloads (Pure)

Abstract

Neuropathological conditions might affect adult granulogenesis in the adult human dentate gyrus. However, radial glial cells (RGCs) have not been well characterized during human development and aging. We have previously described progenitor and neuronal layer establishment in the hippocampal pyramidal layer and dentate gyrus from embryonic life until mid-gestation. Here, we describe RGC subtypes in the hippocampus from 13 gestational weeks (GW) to mid-gestation and characterize their evolution and the dynamics of neurogenesis from mid-gestation to adulthood in normal and Alzheimer's disease (AD) subjects. In the pyramidal ventricular zone (VZ), RGC density declined with neurogenesis from mid-gestation until the perinatal period. In the dentate area, morphologic and antigenic differences among RGCs were observed from early ages of development to adulthood. Density and proliferative capacity of dentate RGCs as well as neurogenesis were strongly reduced during childhood until 5 years, few DCX+ cells are seen in adults. The dentate gyrus of both control and AD individuals showed Nestin+ and/or GFAPδ+ cells displaying different morphologies. In conclusion, pools of morphologically, antigenically, and topographically diverse neural progenitor cells are present in the human hippocampus from early developmental stages until adulthood, including in AD patients, while their neurogenic potential seems negligible in the adult.

Original language	English
Journal	Cerebral cortex (New York, N.Y. : 1991)
Early online date	2 May 2018
DOIs	https://doi.org/10.1093/cercor/bhy096
Publication status	E-pub ahead of print - 2 May 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/cercor/bhy096

Hippocampal radial glial subtypes_CIPRIANI_Accepted6April2018_GREEN AAMAccepted author manuscript, 483 KB

Cite this

Cipriani, S., Ferrer, I., Aronica, E., Kovacs, G. G., Verney, C., Nardelli, J., Khung, S., Delezoide, A.-L., Milenkovic, I., Rasika, S., Manivet, P., Benifla, J.-L., Deriot, N., Gressens, P., & Adle-Biassette, H. (2018). Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults. Cerebral cortex (New York, N.Y. : 1991). Advance online publication. https://doi.org/10.1093/cercor/bhy096

@article{b6c9caccf9fc412baf88a8ca440faeff,

title = "Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults",

abstract = "Neuropathological conditions might affect adult granulogenesis in the adult human dentate gyrus. However, radial glial cells (RGCs) have not been well characterized during human development and aging. We have previously described progenitor and neuronal layer establishment in the hippocampal pyramidal layer and dentate gyrus from embryonic life until mid-gestation. Here, we describe RGC subtypes in the hippocampus from 13 gestational weeks (GW) to mid-gestation and characterize their evolution and the dynamics of neurogenesis from mid-gestation to adulthood in normal and Alzheimer's disease (AD) subjects. In the pyramidal ventricular zone (VZ), RGC density declined with neurogenesis from mid-gestation until the perinatal period. In the dentate area, morphologic and antigenic differences among RGCs were observed from early ages of development to adulthood. Density and proliferative capacity of dentate RGCs as well as neurogenesis were strongly reduced during childhood until 5 years, few DCX+ cells are seen in adults. The dentate gyrus of both control and AD individuals showed Nestin+ and/or GFAPδ+ cells displaying different morphologies. In conclusion, pools of morphologically, antigenically, and topographically diverse neural progenitor cells are present in the human hippocampus from early developmental stages until adulthood, including in AD patients, while their neurogenic potential seems negligible in the adult.",

author = "Sara Cipriani and Isidre Ferrer and Eleonora Aronica and Kovacs, {Gabor G} and Catherine Verney and Jeannette Nardelli and Suonavy Khung and Anne-Lise Delezoide and Ivan Milenkovic and Sowmyalakshmi Rasika and Philippe Manivet and Jean-Louis Benifla and Nicolas Deriot and Pierre Gressens and Homa Adle-Biassette",

year = "2018",

month = may,

day = "2",

doi = "10.1093/cercor/bhy096",

language = "English",

journal = "Cerebral cortex (New York, N.Y. : 1991)",

issn = "1047-3211",

publisher = "Oxford University Press",

}

Cipriani, S, Ferrer, I, Aronica, E, Kovacs, GG, Verney, C, Nardelli, J, Khung, S, Delezoide, A-L, Milenkovic, I, Rasika, S, Manivet, P, Benifla, J-L, Deriot, N, Gressens, P & Adle-Biassette, H 2018, 'Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults', Cerebral cortex (New York, N.Y. : 1991). https://doi.org/10.1093/cercor/bhy096

TY - JOUR

T1 - Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults

AU - Cipriani, Sara

AU - Ferrer, Isidre

AU - Aronica, Eleonora

AU - Kovacs, Gabor G

AU - Verney, Catherine

AU - Nardelli, Jeannette

AU - Khung, Suonavy

AU - Delezoide, Anne-Lise

AU - Milenkovic, Ivan

AU - Rasika, Sowmyalakshmi

AU - Manivet, Philippe

AU - Benifla, Jean-Louis

AU - Deriot, Nicolas

AU - Gressens, Pierre

AU - Adle-Biassette, Homa

PY - 2018/5/2

Y1 - 2018/5/2

N2 - Neuropathological conditions might affect adult granulogenesis in the adult human dentate gyrus. However, radial glial cells (RGCs) have not been well characterized during human development and aging. We have previously described progenitor and neuronal layer establishment in the hippocampal pyramidal layer and dentate gyrus from embryonic life until mid-gestation. Here, we describe RGC subtypes in the hippocampus from 13 gestational weeks (GW) to mid-gestation and characterize their evolution and the dynamics of neurogenesis from mid-gestation to adulthood in normal and Alzheimer's disease (AD) subjects. In the pyramidal ventricular zone (VZ), RGC density declined with neurogenesis from mid-gestation until the perinatal period. In the dentate area, morphologic and antigenic differences among RGCs were observed from early ages of development to adulthood. Density and proliferative capacity of dentate RGCs as well as neurogenesis were strongly reduced during childhood until 5 years, few DCX+ cells are seen in adults. The dentate gyrus of both control and AD individuals showed Nestin+ and/or GFAPδ+ cells displaying different morphologies. In conclusion, pools of morphologically, antigenically, and topographically diverse neural progenitor cells are present in the human hippocampus from early developmental stages until adulthood, including in AD patients, while their neurogenic potential seems negligible in the adult.

AB - Neuropathological conditions might affect adult granulogenesis in the adult human dentate gyrus. However, radial glial cells (RGCs) have not been well characterized during human development and aging. We have previously described progenitor and neuronal layer establishment in the hippocampal pyramidal layer and dentate gyrus from embryonic life until mid-gestation. Here, we describe RGC subtypes in the hippocampus from 13 gestational weeks (GW) to mid-gestation and characterize their evolution and the dynamics of neurogenesis from mid-gestation to adulthood in normal and Alzheimer's disease (AD) subjects. In the pyramidal ventricular zone (VZ), RGC density declined with neurogenesis from mid-gestation until the perinatal period. In the dentate area, morphologic and antigenic differences among RGCs were observed from early ages of development to adulthood. Density and proliferative capacity of dentate RGCs as well as neurogenesis were strongly reduced during childhood until 5 years, few DCX+ cells are seen in adults. The dentate gyrus of both control and AD individuals showed Nestin+ and/or GFAPδ+ cells displaying different morphologies. In conclusion, pools of morphologically, antigenically, and topographically diverse neural progenitor cells are present in the human hippocampus from early developmental stages until adulthood, including in AD patients, while their neurogenic potential seems negligible in the adult.

U2 - 10.1093/cercor/bhy096

DO - 10.1093/cercor/bhy096

M3 - Article

C2 - 29722804

SN - 1047-3211

JO - Cerebral cortex (New York, N.Y. : 1991)

JF - Cerebral cortex (New York, N.Y. : 1991)

ER -

Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this