Hippocampal subfield volumes are associated with verbal memory after first-ever ischemic stroke

Mohamed Salah Khlif; Laura J. Bird; Carolina Restrepo; Wasim Khan; Emilio Werden; Natalia Egorova-Brumley; Amy Brodtmann

doi:10.1002/dad2.12195

Original language	English
Article number	e12195
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	13
Issue number	1
Early online date	12 Jun 2021
DOIs	https://doi.org/10.1002/dad2.12195
E-pub ahead of print	12 Jun 2021
Published	2021
Additional links	Link to publication in Scopus

Bibliographical note

Funding Information: This work was supported by NHMRC grant (APP1020526), Brain Foundation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation. N.E. was supported by ARC grant (DE180100893). The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government (Operational Infrastructure Support Grant) and the support from the HPC system operated by Research Platform Services at University of Melbourne. The authors acknowledge the facilities, and scientific and technical assistance of the National Imaging Facility at the Florey. Funding Information: NHMRC, Grant/Award Number: APP1020526; Brain Foundation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation. N.E., Grant/Award Number: DE180100893 This work was supported by NHMRC grant (APP1020526), Brain Foun-dation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation. N.E. was supported by ARC grant (DE180100893). The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government (Operational Infrastructure Support Grant) and the support from the HPC system operated by Research Platform Services at University of Melbourne. The authors acknowledge the facilities, and scientific and technical assistance of the National Imaging Facility at the Florey. Publisher Copyright: © 2021 The Authors. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

Abstract

Introduction: Hippocampal subfield volumes are more closely associated with cognitive impairment than whole hippocampal volume in many diseases. Both memory and whole hippocampal volume decline after stroke. Understanding the subfields’ temporal evolution could reveal valuable information about post-stroke memory. Methods: We sampled 120 participants (38 control, 82 stroke), with cognitive testing and 3T-MRI available at 3 months and 3 years, from the Cognition and Neocortical Volume after Stroke (CANVAS) study. Verbal memory was assessed using the Hopkins Verbal Learning Test-Revised. Subfields were delineated using FreeSurfer. We used partial Pearson’s correlation to assess the associations between subfield volumes and verbal memory scores, adjusting for years of education, sex, and stroke side. Results: The left cornu ammonis areas 2/3 and hippocampal tail volumes were significantly associated with verbal memory 3-month post-stroke. At 3 years, the associations became stronger and involved more subfields. Discussion: Hippocampal subfield volumes may be a useful biomarker for post-stroke cognitive impairment.

King's College London

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