Hippocampal volume is an independent predictor of cognitive performance in CADASIL

TY - JOUR

T1 - Hippocampal volume is an independent predictor of cognitive performance in CADASIL

AU - O'Sullivan, Michael

AU - Ngo, Elmar

AU - Viswanathan, Anand

AU - Jouvent, Eric

AU - Gschwendtner, Andreas

AU - Saemann, Philipp G.

AU - Duering, Marco

AU - Pachai, Chahin

AU - Bousser, Marie-Germaine

AU - Chabriat, Hugues

AU - Dichgans, Martin

PY - 2009/6

Y1 - 2009/6

N2 - Recent evidence suggests that hippocampal changes are present in vascular cognitive impairment but their importance and relationship with ischaemic mechanisms remain controversial. To investigate these issues we performed MRI and cognitive assessment in a large cohort (n = 144) of patients with CADASIL, a hereditary small vessel disease and model of pure vascular cognitive impairment. Dementia status was ascribed according to DSM-IV and global cognitive function assessed with the Minimental State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS). Hippocampal volume (HV) correlated with age (r= -0.33, p <0.001), brain volume (r= 0.39, p <0.001.) and lacunar lesion volume (r= -0.23, p = 0.008), but not white matter lesions or microhaemorrhages. HV was reduced in dementia (2272 +/- 333 mm(3) versus 2642 +/- 349 mm(3), p <0.001) in the whole cohort and the subgroup progressing to dementia before age 60. HV correlated with MMSE (r = 0.30, p <0.001), MDRS (r= 0.40, p <0.001) and in a multivariate model predicted cognition independent of typical vascular lesions and whole brain atrophy. These findings strengthen the view that hippocampal atrophy is an important pathway of cognitive impairment in vascular as well as degenerative disease. (C) 2007 Elsevier Inc. All rights reserved.

AB - Recent evidence suggests that hippocampal changes are present in vascular cognitive impairment but their importance and relationship with ischaemic mechanisms remain controversial. To investigate these issues we performed MRI and cognitive assessment in a large cohort (n = 144) of patients with CADASIL, a hereditary small vessel disease and model of pure vascular cognitive impairment. Dementia status was ascribed according to DSM-IV and global cognitive function assessed with the Minimental State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS). Hippocampal volume (HV) correlated with age (r= -0.33, p <0.001), brain volume (r= 0.39, p <0.001.) and lacunar lesion volume (r= -0.23, p = 0.008), but not white matter lesions or microhaemorrhages. HV was reduced in dementia (2272 +/- 333 mm(3) versus 2642 +/- 349 mm(3), p <0.001) in the whole cohort and the subgroup progressing to dementia before age 60. HV correlated with MMSE (r = 0.30, p <0.001), MDRS (r= 0.40, p <0.001) and in a multivariate model predicted cognition independent of typical vascular lesions and whole brain atrophy. These findings strengthen the view that hippocampal atrophy is an important pathway of cognitive impairment in vascular as well as degenerative disease. (C) 2007 Elsevier Inc. All rights reserved.

KW - ENTORHINAL CORTEX

KW - IMPAIRMENT

KW - Vascular dementia

KW - Hippocampus

KW - ALZHEIMERS-DISEASE

KW - ISCHEMIC VASCULAR DEMENTIA

KW - AD

KW - CADASIL

KW - MRI

KW - MEMORY

KW - CORTICAL ATROPHY

KW - RATES

KW - LESIONS

KW - Small vessel disease

U2 - 10.1016/j.neurobiolaging.2007.09.002

DO - 10.1016/j.neurobiolaging.2007.09.002

M3 - Article

SN - 0197-4580

VL - 30

SP - 890

EP - 897

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 6

ER -