Histological heterogeneity in primary and metastatic classic combined hepatocellular-cholangiocarcinoma: a case series

Claudio de Vito*, Debashis Sarker, Paul Ross, Nigel Heaton, Alberto Quaglia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare and aggressive primary liver cancer with both hepatocellular and cholangiocellular differentiation. Due to its bi-phenotypic component, cHCC-CC is a heterogeneous tumour and histopathological analysis of metastatic deposits is poorly characterized. In this retrospective study, we describe four patients in whom the histology from resected specimens of both primary and recurrent and/or metastatic tumour was available for comparison and immunohistochemical characterization. Our study shows that recurrent or metastatic deposits replicate the heterogeneity of the primary cHCC-CC, that even originally small foci of divergent differentiation can become predominant later on and that hepatocellular and cholangiocellular components can show different tropism in distant organs. In our experience, the behaviour of recurrent/metastatic cHCC-CC is unpredictable and histological examination is necessary to guide treatment options at present.

Original languageEnglish
Pages (from-to)619-629
Number of pages11
JournalVirchows Archiv : an international journal of pathology
Volume471
Issue number5
Early online date13 Jul 2017
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Combined hepatocellular-cholangiocarcinoma
  • Heterogeneity
  • Metastasis

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