History of suicide attempts among patients with depression in the GENDEP project

Nader Perroud; Rudolf Uher; Joanna Hauser; Marcella Rietschel; Neven Henigsberg; Anna Placentino; Dejan Kozel; Wolfgang Maier; Ole Mors; Daniel Souery; Monika Dmitrzak-Weglarz; Lisbeth Jorgensen; Zrnka Kovacic; Caterina Giovannini; Julien Mendlewicz; Astrid Zobel; Jana Strohmaier; Peter McGuffin; Katherine J. Aitchison; Anne Farmer

doi:10.1016/j.jad.2009.09.001

History of suicide attempts among patients with depression in the GENDEP project

Nader Perroud, Rudolf Uher, Joanna Hauser, Marcella Rietschel, Neven Henigsberg, Anna Placentino, Dejan Kozel, Wolfgang Maier, Ole Mors, Daniel Souery, Monika Dmitrzak-Weglarz, Lisbeth Jorgensen, Zrnka Kovacic, Caterina Giovannini, Julien Mendlewicz, Astrid Zobel, Jana Strohmaier, Peter McGuffin, Katherine J. Aitchison, Anne Farmer

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Background: It has been proposed that a history of suicide attempts could be a correlate of severe depressive disorder and that suicide attempters (SA) could represent a particular subtype of subjects suffering from major depressive disorder. We investigated clinical and demographic characteristics associated with SA and tested the hypothesis that a history of suicide attempts predicts poor response to antidepressants. Methods: One-hundred-and-forty-one SA and 670 non-SA subjects with major depressive disorder (MOD) were treated for twelve weeks with escitalopram or nortriptyline in GENDEP, a part-randomized multi-center clinical and pharmacogenetic study. Baseline characteristics were compared using linear and logistic regression. Linear mixed models were used to analyse continuous outcomes during the twelve weeks of follow-up. Results: At baseline, SA subjects suffered from more severe depression (mean Montgomery-Asberg Depression Rating Scale: 30.29 (7.61) vs 28.43 (6.54),p = 0.0002), reported higher level of suicidal ideation (1.21 (0.82) vs 0.73 (0.48), p

Original language	English
Pages (from-to)	131 - 137
Number of pages	7
Journal	Journal of Affective Disorders
Volume	123
Issue number	1-3
DOIs	https://doi.org/10.1016/j.jad.2009.09.001
Publication status	Published - Jun 2010

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Perroud, N., Uher, R., Hauser, J., Rietschel, M., Henigsberg, N., Placentino, A., Kozel, D., Maier, W., Mors, O., Souery, D., Dmitrzak-Weglarz, M., Jorgensen, L., Kovacic, Z., Giovannini, C., Mendlewicz, J., Zobel, A., Strohmaier, J., McGuffin, P., Aitchison, K. J., & Farmer, A. (2010). History of suicide attempts among patients with depression in the GENDEP project. Journal of Affective Disorders, 123(1-3), 131 - 137. https://doi.org/10.1016/j.jad.2009.09.001

@article{c425ec873b9348edb57bd09ffaa570cb,

title = "History of suicide attempts among patients with depression in the GENDEP project",

abstract = "Background: It has been proposed that a history of suicide attempts could be a correlate of severe depressive disorder and that suicide attempters (SA) could represent a particular subtype of subjects suffering from major depressive disorder. We investigated clinical and demographic characteristics associated with SA and tested the hypothesis that a history of suicide attempts predicts poor response to antidepressants. Methods: One-hundred-and-forty-one SA and 670 non-SA subjects with major depressive disorder (MOD) were treated for twelve weeks with escitalopram or nortriptyline in GENDEP, a part-randomized multi-center clinical and pharmacogenetic study. Baseline characteristics were compared using linear and logistic regression. Linear mixed models were used to analyse continuous outcomes during the twelve weeks of follow-up. Results: At baseline, SA subjects suffered from more severe depression (mean Montgomery-Asberg Depression Rating Scale: 30.29 (7.61) vs 28.43 (6.54),p = 0.0002), reported higher level of suicidal ideation (1.21 (0.82) vs 0.73 (0.48), p ",

author = "Nader Perroud and Rudolf Uher and Joanna Hauser and Marcella Rietschel and Neven Henigsberg and Anna Placentino and Dejan Kozel and Wolfgang Maier and Ole Mors and Daniel Souery and Monika Dmitrzak-Weglarz and Lisbeth Jorgensen and Zrnka Kovacic and Caterina Giovannini and Julien Mendlewicz and Astrid Zobel and Jana Strohmaier and Peter McGuffin and Aitchison, {Katherine J.} and Anne Farmer",

year = "2010",

month = jun,

doi = "10.1016/j.jad.2009.09.001",

language = "English",

volume = "123",

pages = "131 -- 137",

journal = "Journal of Affective Disorders",

issn = "1573-2517",

publisher = "Elsevier",

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Perroud, N, Uher, R, Hauser, J, Rietschel, M, Henigsberg, N, Placentino, A, Kozel, D, Maier, W, Mors, O, Souery, D, Dmitrzak-Weglarz, M, Jorgensen, L, Kovacic, Z, Giovannini, C, Mendlewicz, J, Zobel, A, Strohmaier, J, McGuffin, P , Aitchison, KJ & Farmer, A 2010, 'History of suicide attempts among patients with depression in the GENDEP project', Journal of Affective Disorders, vol. 123, no. 1-3, pp. 131 - 137. https://doi.org/10.1016/j.jad.2009.09.001

TY - JOUR

T1 - History of suicide attempts among patients with depression in the GENDEP project

AU - Perroud, Nader

AU - Uher, Rudolf

AU - Hauser, Joanna

AU - Rietschel, Marcella

AU - Henigsberg, Neven

AU - Placentino, Anna

AU - Kozel, Dejan

AU - Maier, Wolfgang

AU - Mors, Ole

AU - Souery, Daniel

AU - Dmitrzak-Weglarz, Monika

AU - Jorgensen, Lisbeth

AU - Kovacic, Zrnka

AU - Giovannini, Caterina

AU - Mendlewicz, Julien

AU - Zobel, Astrid

AU - Strohmaier, Jana

AU - McGuffin, Peter

AU - Aitchison, Katherine J.

AU - Farmer, Anne

PY - 2010/6

Y1 - 2010/6

N2 - Background: It has been proposed that a history of suicide attempts could be a correlate of severe depressive disorder and that suicide attempters (SA) could represent a particular subtype of subjects suffering from major depressive disorder. We investigated clinical and demographic characteristics associated with SA and tested the hypothesis that a history of suicide attempts predicts poor response to antidepressants. Methods: One-hundred-and-forty-one SA and 670 non-SA subjects with major depressive disorder (MOD) were treated for twelve weeks with escitalopram or nortriptyline in GENDEP, a part-randomized multi-center clinical and pharmacogenetic study. Baseline characteristics were compared using linear and logistic regression. Linear mixed models were used to analyse continuous outcomes during the twelve weeks of follow-up. Results: At baseline, SA subjects suffered from more severe depression (mean Montgomery-Asberg Depression Rating Scale: 30.29 (7.61) vs 28.43 (6.54),p = 0.0002), reported higher level of suicidal ideation (1.21 (0.82) vs 0.73 (0.48), p

AB - Background: It has been proposed that a history of suicide attempts could be a correlate of severe depressive disorder and that suicide attempters (SA) could represent a particular subtype of subjects suffering from major depressive disorder. We investigated clinical and demographic characteristics associated with SA and tested the hypothesis that a history of suicide attempts predicts poor response to antidepressants. Methods: One-hundred-and-forty-one SA and 670 non-SA subjects with major depressive disorder (MOD) were treated for twelve weeks with escitalopram or nortriptyline in GENDEP, a part-randomized multi-center clinical and pharmacogenetic study. Baseline characteristics were compared using linear and logistic regression. Linear mixed models were used to analyse continuous outcomes during the twelve weeks of follow-up. Results: At baseline, SA subjects suffered from more severe depression (mean Montgomery-Asberg Depression Rating Scale: 30.29 (7.61) vs 28.43 (6.54),p = 0.0002), reported higher level of suicidal ideation (1.21 (0.82) vs 0.73 (0.48), p

U2 - 10.1016/j.jad.2009.09.001

DO - 10.1016/j.jad.2009.09.001

M3 - Article

SN - 1573-2517

VL - 123

SP - 131

EP - 137

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 1-3

ER -

History of suicide attempts among patients with depression in the GENDEP project

Abstract

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