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HIV: ageing, cognition and neuroimaging at 4 year follow-up

Research output: Contribution to journalArticle

B I Haynes, Mervi Pitkänen, R Kulasegaram, S.J. Casey, M. Schutte, K. Towgood, Barry Stephen Peters, Gareth John Barker, Michael David Kopelman

Original languageEnglish
Early online date14 Feb 2018
Publication statusPublished - 2018


  • HIV ageing, cognition and_HAYNES_Firstonline14February2018_GREEN AAM

    Haynes_HIVAgeCog_HIVMedicine_R2.pdf, 501 KB, application/pdf


    Accepted author manuscript


    This is the peer reviewed version of the following article:

    Article ID: HIV12598
    Article DOI: 10.1111/hiv.12598
    Internal Article ID: 14907660
    Article: Human Immunodeficiency Virus: ageing, cognition and neuroimaging at 4 year follow-up.
    Journal: HIV Medicine

    which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

King's Authors


Objective: To investigate the hypothesis of accelerated cognitive ageing in HIV positive individuals using longitudinal assessment of cognitive performance and quantitative MRI.
Methods: We assessed a broad cognitive battery and quantitative MRI metrics (voxel based morphometry: VBM and diffusion tensor imaging: DTI) in asymptomatic HIV positive men who have sex with men (15 aged 20-40 years and 15 aged ≥50 years), and seronegative matched controls (nine aged 20-40 years and 16 aged ≥50 years).
Results: Being HIV positive was associated with a greater decrease in executive function, and global cognition. Additionally, using DTI, the HIV Group had a greater increase in mean diffusivity, but we did not find group differences on volume change using VBM. With respect to the HIV by Age Group interaction, this was statistically significant for change in global cognition, with older HIV positive individuals showing greater global cognitive decline, but there were no significant interactions on other measures. Lastly, change in cognitive performance was correlated with change in the DTI measures, and this effect was stronger for the HIV positive participants.
Conclusions: In the present study, we found some evidence for accelerated ageing in HIV with a statistically significant HIV by Age Group interaction in global cognition, although this interaction could not be explained by the imaging findings. Moreover, we also found that change in cognitive performance correlated with change in the DTI measures, and this effect was stronger for the HIV positive participants. This will need replication in larger studies using a similar follow-up delay.

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