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HIV: ageing, cognition and neuroimaging at 4 year follow-up

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HIV : ageing, cognition and neuroimaging at 4 year follow-up. / Haynes, B I; Pitkänen, Mervi; Kulasegaram, R; Casey, S.J. ; Schutte, M.; Towgood, K.; Peters, Barry Stephen; Barker, Gareth John; Kopelman, Michael David.

In: HIV MEDICINE, 2018.

Research output: Contribution to journalArticle

Harvard

Haynes, BI, Pitkänen, M, Kulasegaram, R, Casey, SJ, Schutte, M, Towgood, K, Peters, BS, Barker, GJ & Kopelman, MD 2018, 'HIV: ageing, cognition and neuroimaging at 4 year follow-up', HIV MEDICINE. https://doi.org/10.1111/hiv.12598, https://doi.org/10.1111/hiv.12598

APA

Haynes, B. I., Pitkänen, M., Kulasegaram, R., Casey, S. J., Schutte, M., Towgood, K., ... Kopelman, M. D. (2018). HIV: ageing, cognition and neuroimaging at 4 year follow-up. HIV MEDICINE. https://doi.org/10.1111/hiv.12598, https://doi.org/10.1111/hiv.12598

Vancouver

Haynes BI, Pitkänen M, Kulasegaram R, Casey SJ, Schutte M, Towgood K et al. HIV: ageing, cognition and neuroimaging at 4 year follow-up. HIV MEDICINE. 2018. https://doi.org/10.1111/hiv.12598, https://doi.org/10.1111/hiv.12598

Author

Haynes, B I ; Pitkänen, Mervi ; Kulasegaram, R ; Casey, S.J. ; Schutte, M. ; Towgood, K. ; Peters, Barry Stephen ; Barker, Gareth John ; Kopelman, Michael David. / HIV : ageing, cognition and neuroimaging at 4 year follow-up. In: HIV MEDICINE. 2018.

Bibtex Download

@article{070444379f5d438f8a3518be3a75021c,
title = "HIV: ageing, cognition and neuroimaging at 4 year follow-up",
abstract = "Objective: To investigate the hypothesis of accelerated cognitive ageing in HIV positive individuals using longitudinal assessment of cognitive performance and quantitative MRI. Methods: We assessed a broad cognitive battery and quantitative MRI metrics (voxel based morphometry: VBM and diffusion tensor imaging: DTI) in asymptomatic HIV positive men who have sex with men (15 aged 20-40 years and 15 aged ≥50 years), and seronegative matched controls (nine aged 20-40 years and 16 aged ≥50 years). Results: Being HIV positive was associated with a greater decrease in executive function, and global cognition. Additionally, using DTI, the HIV Group had a greater increase in mean diffusivity, but we did not find group differences on volume change using VBM. With respect to the HIV by Age Group interaction, this was statistically significant for change in global cognition, with older HIV positive individuals showing greater global cognitive decline, but there were no significant interactions on other measures. Lastly, change in cognitive performance was correlated with change in the DTI measures, and this effect was stronger for the HIV positive participants. Conclusions: In the present study, we found some evidence for accelerated ageing in HIV with a statistically significant HIV by Age Group interaction in global cognition, although this interaction could not be explained by the imaging findings. Moreover, we also found that change in cognitive performance correlated with change in the DTI measures, and this effect was stronger for the HIV positive participants. This will need replication in larger studies using a similar follow-up delay.",
author = "Haynes, {B I} and Mervi Pitk{\"a}nen and R Kulasegaram and S.J. Casey and M. Schutte and K. Towgood and Peters, {Barry Stephen} and Barker, {Gareth John} and Kopelman, {Michael David}",
year = "2018",
doi = "10.1111/hiv.12598",
language = "English",
journal = "HIV MEDICINE",
issn = "1464-2662",
publisher = "Wiley-Blackwell",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - HIV

T2 - ageing, cognition and neuroimaging at 4 year follow-up

AU - Haynes, B I

AU - Pitkänen, Mervi

AU - Kulasegaram, R

AU - Casey, S.J.

AU - Schutte, M.

AU - Towgood, K.

AU - Peters, Barry Stephen

AU - Barker, Gareth John

AU - Kopelman, Michael David

PY - 2018

Y1 - 2018

N2 - Objective: To investigate the hypothesis of accelerated cognitive ageing in HIV positive individuals using longitudinal assessment of cognitive performance and quantitative MRI. Methods: We assessed a broad cognitive battery and quantitative MRI metrics (voxel based morphometry: VBM and diffusion tensor imaging: DTI) in asymptomatic HIV positive men who have sex with men (15 aged 20-40 years and 15 aged ≥50 years), and seronegative matched controls (nine aged 20-40 years and 16 aged ≥50 years). Results: Being HIV positive was associated with a greater decrease in executive function, and global cognition. Additionally, using DTI, the HIV Group had a greater increase in mean diffusivity, but we did not find group differences on volume change using VBM. With respect to the HIV by Age Group interaction, this was statistically significant for change in global cognition, with older HIV positive individuals showing greater global cognitive decline, but there were no significant interactions on other measures. Lastly, change in cognitive performance was correlated with change in the DTI measures, and this effect was stronger for the HIV positive participants. Conclusions: In the present study, we found some evidence for accelerated ageing in HIV with a statistically significant HIV by Age Group interaction in global cognition, although this interaction could not be explained by the imaging findings. Moreover, we also found that change in cognitive performance correlated with change in the DTI measures, and this effect was stronger for the HIV positive participants. This will need replication in larger studies using a similar follow-up delay.

AB - Objective: To investigate the hypothesis of accelerated cognitive ageing in HIV positive individuals using longitudinal assessment of cognitive performance and quantitative MRI. Methods: We assessed a broad cognitive battery and quantitative MRI metrics (voxel based morphometry: VBM and diffusion tensor imaging: DTI) in asymptomatic HIV positive men who have sex with men (15 aged 20-40 years and 15 aged ≥50 years), and seronegative matched controls (nine aged 20-40 years and 16 aged ≥50 years). Results: Being HIV positive was associated with a greater decrease in executive function, and global cognition. Additionally, using DTI, the HIV Group had a greater increase in mean diffusivity, but we did not find group differences on volume change using VBM. With respect to the HIV by Age Group interaction, this was statistically significant for change in global cognition, with older HIV positive individuals showing greater global cognitive decline, but there were no significant interactions on other measures. Lastly, change in cognitive performance was correlated with change in the DTI measures, and this effect was stronger for the HIV positive participants. Conclusions: In the present study, we found some evidence for accelerated ageing in HIV with a statistically significant HIV by Age Group interaction in global cognition, although this interaction could not be explained by the imaging findings. Moreover, we also found that change in cognitive performance correlated with change in the DTI measures, and this effect was stronger for the HIV positive participants. This will need replication in larger studies using a similar follow-up delay.

U2 - 10.1111/hiv.12598

DO - 10.1111/hiv.12598

M3 - Article

JO - HIV MEDICINE

JF - HIV MEDICINE

SN - 1464-2662

ER -

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