HIV-1 accessory proteins - Ensuring viral survival in a hostile environment

TY - JOUR

T1 - HIV-1 accessory proteins - Ensuring viral survival in a hostile environment

AU - Malim, M H

AU - Emerman, M

PY - 2008/6/12

Y1 - 2008/6/12

N2 - One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes them from other retroviruses is the array of "accessory" proteins they encode. Here, we discuss recent advances in understanding the interactions of the HIV-1 Nef, Vif, Vpu, and Vpr proteins with factors and pathways expressed in cells of the immune system. In at least three instances, the principal activity of the accessory proteins appears to be evasion from various forms of cell-mediated (or intrinsic), antiviral resistance. Broadly speaking, the HIV-1 accessory proteins modify the local environment within infected cells to ensure viral persistence, replication, dissemination, and transmission

AB - One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes them from other retroviruses is the array of "accessory" proteins they encode. Here, we discuss recent advances in understanding the interactions of the HIV-1 Nef, Vif, Vpu, and Vpr proteins with factors and pathways expressed in cells of the immune system. In at least three instances, the principal activity of the accessory proteins appears to be evasion from various forms of cell-mediated (or intrinsic), antiviral resistance. Broadly speaking, the HIV-1 accessory proteins modify the local environment within infected cells to ensure viral persistence, replication, dissemination, and transmission

U2 - 10.1016/j.chom.2008.04.008

DO - 10.1016/j.chom.2008.04.008

M3 - Literature review

SN - 1934-6069

VL - 3

SP - 388

EP - 398

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -