HIV-1 and interferons: who's interfering with whom?

TY - JOUR

T1 - HIV-1 and interferons

T2 - who's interfering with whom?

AU - Doyle, Tomas

AU - Goujon, Caroline

AU - Malim, Michael H

PY - 2015

Y1 - 2015

N2 - The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who are not receiving antiretroviral therapy produces a clear but transient decrease in plasma viral load. Conversely, studies of chronic HIV-1 infection in humans and SIV-infected animal models of AIDS show positive correlations between elevated plasma levels of IFNs, increased expression of IFN-stimulated genes (ISGs), biomarkers of inflammation and disease progression. In this Review, we discuss the evidence that IFNs can control HIV-1 replication in vivo and debate the controversial role of IFNs in promoting the pathological sequelae of chronic HIV-1 infection.

AB - The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who are not receiving antiretroviral therapy produces a clear but transient decrease in plasma viral load. Conversely, studies of chronic HIV-1 infection in humans and SIV-infected animal models of AIDS show positive correlations between elevated plasma levels of IFNs, increased expression of IFN-stimulated genes (ISGs), biomarkers of inflammation and disease progression. In this Review, we discuss the evidence that IFNs can control HIV-1 replication in vivo and debate the controversial role of IFNs in promoting the pathological sequelae of chronic HIV-1 infection.

U2 - 10.1038/nrmicro3449

DO - 10.1038/nrmicro3449

M3 - Review article

C2 - 25915633

SN - 1740-1526

VL - 13

SP - 403

EP - 413

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 7

ER -