Research output: Contribution to journal › Article › peer-review
Metab Algeffari, Sufyan Hussain, Turki Almogbel, Mansour Alsharidah, Habibah Alghadouni, Farid Mahmood
Original language | English |
---|---|
Pages (from-to) | 990-993 |
Number of pages | 4 |
Journal | Diabetes Care |
Volume | 45 |
Issue number | 4 |
Early online date | 17 Feb 2022 |
DOIs | |
Accepted/In press | 20 Jan 2022 |
E-pub ahead of print | 17 Feb 2022 |
Published | 1 Apr 2022 |
Additional links |
dc211655.pdf, 559 KB, application/pdf
Uploaded date:27 May 2022
Version:Final published version
Licence:CC BY
We determined the efficacy of self-administered subcutaneous mini-dose gluca-gon (MDG) to treat fasting-induced hypoglycemia in type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS This was a 4-week randomized, controlled crossover trial of 2-week MDG or 2-week oral glucose tablets (OG, control) involving 17 adults with T1D during Ramadan. RESULTS Compared with OG, MDG demonstrated a significant higher change in blood glucose from baseline to 30 min (∆ t30, P < 0.001) and 1 h (∆ t60, P = 0.02). The efficacy of MDG was preserved following ≥8 h fasting with significantly higher ∆ t30 in MDG (P = 0.01). Over the entire 2 weeks, MDG period had increased time in 70–180 mg/dL (P = 0.009) and less time <70 mg/dL (P = 0.04). MDG use resulted in higher completion of fasts compared with OG (P < 0.001). CONCLUSIONS MDG administration is an effective alternative to OG for prevention and treatment of fasting-induced hypoglycemia, offering improved glycemic control and promoting successful completion of prolonged fasts.
King's College London - Homepage
© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454