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Homeostasis, regeneration and tumour formation in the mammalian epidermis

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)571-582
Number of pages12
JournalInternational Journal of Developmental Biology
Volume62
Issue number6-7-8
DOIs
Publication statusPublished - 2018

King's Authors

Abstract

The epidermis is the outer covering of the skin and provides a protective interface between the body and the environment. It is well established that the epidermis is maintained by stem cells that self-renew and generate differentiated cells. In this review, we discuss how recent technological advances, including single cell transcriptomics and in vivo imaging, have provided new insights into the nature and plasticity of the stem cell compartment and the differing roles of stem cells in homeostasis, wound repair and cancer.

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