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Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs

Research output: Contribution to journalLiterature reviewpeer-review

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Homeostatic Plasticity of Subcellular Neuronal Structures : From Inputs to Outputs. / Wefelmeyer, Winnie; Puhl, Christopher J.; Burrone, Juan.

In: Trends in Neurosciences, Vol. 39, No. 10, 10.2016, p. 656-667.

Research output: Contribution to journalLiterature reviewpeer-review

Harvard

Wefelmeyer, W, Puhl, CJ & Burrone, J 2016, 'Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs', Trends in Neurosciences, vol. 39, no. 10, pp. 656-667. https://doi.org/10.1016/j.tins.2016.08.004

APA

Wefelmeyer, W., Puhl, C. J., & Burrone, J. (2016). Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs. Trends in Neurosciences, 39(10), 656-667. https://doi.org/10.1016/j.tins.2016.08.004

Vancouver

Wefelmeyer W, Puhl CJ, Burrone J. Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs. Trends in Neurosciences. 2016 Oct;39(10):656-667. https://doi.org/10.1016/j.tins.2016.08.004

Author

Wefelmeyer, Winnie ; Puhl, Christopher J. ; Burrone, Juan. / Homeostatic Plasticity of Subcellular Neuronal Structures : From Inputs to Outputs. In: Trends in Neurosciences. 2016 ; Vol. 39, No. 10. pp. 656-667.

Bibtex Download

@article{1b98defbb7b442d48332b5343d57fb51,
title = "Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs",
abstract = "Neurons in the brain are highly plastic, allowing an organism to learn and adapt to its environment. However, this ongoing plasticity is also inherently unstable, potentially leading to aberrant levels of circuit activity. Homeostatic forms of plasticity are thought to provide a means of controlling neuronal activity by avoiding extremes and allowing network stability. Recent work has shown that many of these homeostatic modifications change the structure of subcellular neuronal compartments, ranging from changes to synaptic inputs at both excitatory and inhibitory compartments to modulation of neuronal output through changes at the axon initial segment (AIS) and presynaptic terminals. Here we review these different forms of structural plasticity in neurons and the effects they may have on network function.",
keywords = "homeostatic plasticity, axon initial segment, structural plasticity, dendritic spines, presynaptic terminals",
author = "Winnie Wefelmeyer and Puhl, {Christopher J.} and Juan Burrone",
year = "2016",
month = oct,
doi = "10.1016/j.tins.2016.08.004",
language = "English",
volume = "39",
pages = "656--667",
journal = "Trends in Neurosciences",
issn = "0166-2236",
publisher = "Elsevier Limited",
number = "10",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Homeostatic Plasticity of Subcellular Neuronal Structures

T2 - From Inputs to Outputs

AU - Wefelmeyer, Winnie

AU - Puhl, Christopher J.

AU - Burrone, Juan

PY - 2016/10

Y1 - 2016/10

N2 - Neurons in the brain are highly plastic, allowing an organism to learn and adapt to its environment. However, this ongoing plasticity is also inherently unstable, potentially leading to aberrant levels of circuit activity. Homeostatic forms of plasticity are thought to provide a means of controlling neuronal activity by avoiding extremes and allowing network stability. Recent work has shown that many of these homeostatic modifications change the structure of subcellular neuronal compartments, ranging from changes to synaptic inputs at both excitatory and inhibitory compartments to modulation of neuronal output through changes at the axon initial segment (AIS) and presynaptic terminals. Here we review these different forms of structural plasticity in neurons and the effects they may have on network function.

AB - Neurons in the brain are highly plastic, allowing an organism to learn and adapt to its environment. However, this ongoing plasticity is also inherently unstable, potentially leading to aberrant levels of circuit activity. Homeostatic forms of plasticity are thought to provide a means of controlling neuronal activity by avoiding extremes and allowing network stability. Recent work has shown that many of these homeostatic modifications change the structure of subcellular neuronal compartments, ranging from changes to synaptic inputs at both excitatory and inhibitory compartments to modulation of neuronal output through changes at the axon initial segment (AIS) and presynaptic terminals. Here we review these different forms of structural plasticity in neurons and the effects they may have on network function.

KW - homeostatic plasticity

KW - axon initial segment

KW - structural plasticity

KW - dendritic spines

KW - presynaptic terminals

U2 - 10.1016/j.tins.2016.08.004

DO - 10.1016/j.tins.2016.08.004

M3 - Literature review

VL - 39

SP - 656

EP - 667

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0166-2236

IS - 10

ER -

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