Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs

Winnie Wefelmeyer; Christopher J. Puhl; Juan Burrone

doi:10.1016/j.tins.2016.08.004

Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs

Winnie Wefelmeyer, Christopher J. Puhl, Juan Burrone

Developmental Neurobiology

Research output: Contribution to journal › Literature review › peer-review

73 Citations (Scopus)

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Abstract

Neurons in the brain are highly plastic, allowing an organism to learn and adapt to its environment. However, this ongoing plasticity is also inherently unstable, potentially leading to aberrant levels of circuit activity. Homeostatic forms of plasticity are thought to provide a means of controlling neuronal activity by avoiding extremes and allowing network stability. Recent work has shown that many of these homeostatic modifications change the structure of subcellular neuronal compartments, ranging from changes to synaptic inputs at both excitatory and inhibitory compartments to modulation of neuronal output through changes at the axon initial segment (AIS) and presynaptic terminals. Here we review these different forms of structural plasticity in neurons and the effects they may have on network function.

Original language	English
Pages (from-to)	656-667
Journal	Trends in Neurosciences
Volume	39
Issue number	10
Early online date	13 Sept 2016
DOIs	https://doi.org/10.1016/j.tins.2016.08.004
Publication status	Published - Oct 2016

Keywords

homeostatic plasticity
axon initial segment
structural plasticity
dendritic spines
presynaptic terminals

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10.1016/j.tins.2016.08.004Licence: CC BY

Homeostatic Plasticity of Subcellular_WEFELMEYER_Accepted22August2016_GOLD VoR (CC BY)Final published version, 1.92 MBLicence: CC BY

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title = "Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs",

abstract = "Neurons in the brain are highly plastic, allowing an organism to learn and adapt to its environment. However, this ongoing plasticity is also inherently unstable, potentially leading to aberrant levels of circuit activity. Homeostatic forms of plasticity are thought to provide a means of controlling neuronal activity by avoiding extremes and allowing network stability. Recent work has shown that many of these homeostatic modifications change the structure of subcellular neuronal compartments, ranging from changes to synaptic inputs at both excitatory and inhibitory compartments to modulation of neuronal output through changes at the axon initial segment (AIS) and presynaptic terminals. Here we review these different forms of structural plasticity in neurons and the effects they may have on network function.",

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T2 - From Inputs to Outputs

AU - Wefelmeyer, Winnie

AU - Puhl, Christopher J.

AU - Burrone, Juan

PY - 2016/10

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N2 - Neurons in the brain are highly plastic, allowing an organism to learn and adapt to its environment. However, this ongoing plasticity is also inherently unstable, potentially leading to aberrant levels of circuit activity. Homeostatic forms of plasticity are thought to provide a means of controlling neuronal activity by avoiding extremes and allowing network stability. Recent work has shown that many of these homeostatic modifications change the structure of subcellular neuronal compartments, ranging from changes to synaptic inputs at both excitatory and inhibitory compartments to modulation of neuronal output through changes at the axon initial segment (AIS) and presynaptic terminals. Here we review these different forms of structural plasticity in neurons and the effects they may have on network function.

AB - Neurons in the brain are highly plastic, allowing an organism to learn and adapt to its environment. However, this ongoing plasticity is also inherently unstable, potentially leading to aberrant levels of circuit activity. Homeostatic forms of plasticity are thought to provide a means of controlling neuronal activity by avoiding extremes and allowing network stability. Recent work has shown that many of these homeostatic modifications change the structure of subcellular neuronal compartments, ranging from changes to synaptic inputs at both excitatory and inhibitory compartments to modulation of neuronal output through changes at the axon initial segment (AIS) and presynaptic terminals. Here we review these different forms of structural plasticity in neurons and the effects they may have on network function.

KW - homeostatic plasticity

KW - axon initial segment

KW - structural plasticity

KW - dendritic spines

KW - presynaptic terminals

U2 - 10.1016/j.tins.2016.08.004

DO - 10.1016/j.tins.2016.08.004

M3 - Literature review

SN - 0166-2236

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SP - 656

EP - 667

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 10

ER -

Homeostatic Plasticity of Subcellular Neuronal Structures: From Inputs to Outputs

Abstract

Keywords

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