Homeotic Transformation of Rhombomere Identity After Localized Hoxb1 Misexpression

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129 Citations (Scopus)

Abstract

Segmentation of the hindbrain and branchial region is a conserved feature of head development, involving the nested expression of Hox genes. Although it is presumed that vertebrateHox genes function as segment identifiers, responsible for mediating registration between elements of diverse embryonic origin, this assumption has remained untested. To assess this, retroviral misexpression was combined with orthotopic grafting in chick embryos to generate a mismatch in Hox coding between a specific rhombomere and its corresponding branchial arch. Rhombomere-restricted misexpression of a single gene, Hoxb1, resulted in the homeotic transformation of the rhombomere, revealed by reorganization of motor axon projections.
Original languageEnglish
Pages (from-to)2168 - 2171
Number of pages4
JournalScience
Volume284
Issue number5423
DOIs
Publication statusPublished - 25 Jun 1999

Keywords

  • Animals
  • Axons
  • Branchial Region
  • Cell Differentiation
  • Cell Movement
  • Chick Embryo
  • Cloning, Molecular
  • DNA-Binding Proteins
  • GATA2 Transcription Factor
  • Gene Expression Regulation, Developmental
  • Genes, Homeobox
  • Genetic Vectors
  • Homeodomain Proteins
  • Membrane Glycoproteins
  • Motor Neurons
  • Rhombencephalon
  • Transcription Factors

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