TY - JOUR
T1 - Hormesis and longevity with tannins
T2 - Free of charge or cost-intensive?
AU - Saul, Nadine
AU - Pietsch, Kerstin
AU - Stürzenbaum, Stephen R
AU - Menzel, Ralph
AU - Steinberg, Christian E W
PY - 2013/10
Y1 - 2013/10
N2 - Hormetic lifespan extension is, for obvious reasons, beneficial to an individual. But is this effect really cost-neutral? To answer this question, four tannic polyphenols were tested on the nematode Caenorhabditis elegans. All were able to extend the lifespan, but only some in a hormetic fashion. Additional life trait variables including stress resistance, reproductive behavior, growth, and physical fitness were observed during the exposure to the most life extending concentrations. These traits represent the quality of life and the population fitness, being the most important parameters of a hormetic treatment besides lifespan. Indeed, it emerged that each life-extension is accompanied by a constraining effect in at least one other endpoint, for example growth, mobility, stress resistance, or reproduction. Thus, in this context, longevity could not be considered to be attained for free and therefore it is likely that other hormetic benefits may also incur cost-intensive and unpredictable side-effects.
AB - Hormetic lifespan extension is, for obvious reasons, beneficial to an individual. But is this effect really cost-neutral? To answer this question, four tannic polyphenols were tested on the nematode Caenorhabditis elegans. All were able to extend the lifespan, but only some in a hormetic fashion. Additional life trait variables including stress resistance, reproductive behavior, growth, and physical fitness were observed during the exposure to the most life extending concentrations. These traits represent the quality of life and the population fitness, being the most important parameters of a hormetic treatment besides lifespan. Indeed, it emerged that each life-extension is accompanied by a constraining effect in at least one other endpoint, for example growth, mobility, stress resistance, or reproduction. Thus, in this context, longevity could not be considered to be attained for free and therefore it is likely that other hormetic benefits may also incur cost-intensive and unpredictable side-effects.
U2 - 10.1016/j.chemosphere.2013.05.069
DO - 10.1016/j.chemosphere.2013.05.069
M3 - Article
C2 - 23876505
SN - 0045-6535
VL - 93
SP - 1005
EP - 1008
JO - Chemosphere
JF - Chemosphere
IS - 6
ER -