Host–Pathogen Interactions during Female Genital Tract Infections

Marina Pekmezovic; Selene Mogavero; Julian R. Naglik; Bernhard Hube

doi:10.1016/j.tim.2019.07.006

Host–Pathogen Interactions during Female Genital Tract Infections

Marina Pekmezovic, Selene Mogavero, Julian R. Naglik, Bernhard Hube^*

^*Corresponding author for this work

Centre for Host Microbiome Interactions

Research output: Contribution to journal › Review article › peer-review

53 Citations (Scopus)

Abstract

Dysbiosis in the female genital tract (FGT) is characterized by the overgrowth of pathogenic bacterial, fungal, or protozoan members of the microbiota, leading to symptomatic or asymptomatic infections. In this review, we discuss recent advances in studies dealing with molecular mechanisms of pathogenicity factors of Gardnerella vaginalis, Mycoplasma genitalium, Mycoplasma hominis, Neisseria gonorrhoeae, Streptococcus agalactiae, Chlamydia trachomatis, Trichomonas vaginalis, and Candida spp., as well as their interactions with the host and microbiota in the various niches of the FGT. Taking a holistic approach to identifying fundamental commonalities and differences during these infections could help us to better understand reproductive tract health and improve current prevention and treatment strategies.

Original language	English
Pages (from-to)	982-996
Number of pages	15
Journal	Trends in Microbiology
Volume	27
Issue number	12
DOIs	https://doi.org/10.1016/j.tim.2019.07.006
Publication status	Published - 1 Dec 2019

Keywords

bacteria
Candida
cervicitis
Trichomonas vaginalis
vaginosis
virulence

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10.1016/j.tim.2019.07.006

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title = "Host–Pathogen Interactions during Female Genital Tract Infections",

abstract = "Dysbiosis in the female genital tract (FGT) is characterized by the overgrowth of pathogenic bacterial, fungal, or protozoan members of the microbiota, leading to symptomatic or asymptomatic infections. In this review, we discuss recent advances in studies dealing with molecular mechanisms of pathogenicity factors of Gardnerella vaginalis, Mycoplasma genitalium, Mycoplasma hominis, Neisseria gonorrhoeae, Streptococcus agalactiae, Chlamydia trachomatis, Trichomonas vaginalis, and Candida spp., as well as their interactions with the host and microbiota in the various niches of the FGT. Taking a holistic approach to identifying fundamental commonalities and differences during these infections could help us to better understand reproductive tract health and improve current prevention and treatment strategies.",

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T1 - Host–Pathogen Interactions during Female Genital Tract Infections

AU - Pekmezovic, Marina

AU - Mogavero, Selene

AU - Naglik, Julian R.

AU - Hube, Bernhard

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Dysbiosis in the female genital tract (FGT) is characterized by the overgrowth of pathogenic bacterial, fungal, or protozoan members of the microbiota, leading to symptomatic or asymptomatic infections. In this review, we discuss recent advances in studies dealing with molecular mechanisms of pathogenicity factors of Gardnerella vaginalis, Mycoplasma genitalium, Mycoplasma hominis, Neisseria gonorrhoeae, Streptococcus agalactiae, Chlamydia trachomatis, Trichomonas vaginalis, and Candida spp., as well as their interactions with the host and microbiota in the various niches of the FGT. Taking a holistic approach to identifying fundamental commonalities and differences during these infections could help us to better understand reproductive tract health and improve current prevention and treatment strategies.

AB - Dysbiosis in the female genital tract (FGT) is characterized by the overgrowth of pathogenic bacterial, fungal, or protozoan members of the microbiota, leading to symptomatic or asymptomatic infections. In this review, we discuss recent advances in studies dealing with molecular mechanisms of pathogenicity factors of Gardnerella vaginalis, Mycoplasma genitalium, Mycoplasma hominis, Neisseria gonorrhoeae, Streptococcus agalactiae, Chlamydia trachomatis, Trichomonas vaginalis, and Candida spp., as well as their interactions with the host and microbiota in the various niches of the FGT. Taking a holistic approach to identifying fundamental commonalities and differences during these infections could help us to better understand reproductive tract health and improve current prevention and treatment strategies.

KW - bacteria

KW - Candida

KW - cervicitis

KW - Trichomonas vaginalis

KW - vaginosis

KW - virulence

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DO - 10.1016/j.tim.2019.07.006

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SP - 982

EP - 996

JO - Trends in Microbiology

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ER -

Host–Pathogen Interactions during Female Genital Tract Infections

Abstract

Keywords

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