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Host–Pathogen Interactions during Female Genital Tract Infections

Research output: Contribution to journalReview article

Marina Pekmezovic, Selene Mogavero, Julian R. Naglik, Bernhard Hube

Original languageEnglish
Pages (from-to)982-996
Number of pages15
JournalTrends in Microbiology
Volume27
Issue number12
DOIs
Publication statusPublished - 1 Dec 2019

King's Authors

Abstract

Dysbiosis in the female genital tract (FGT) is characterized by the overgrowth of pathogenic bacterial, fungal, or protozoan members of the microbiota, leading to symptomatic or asymptomatic infections. In this review, we discuss recent advances in studies dealing with molecular mechanisms of pathogenicity factors of Gardnerella vaginalis, Mycoplasma genitalium, Mycoplasma hominis, Neisseria gonorrhoeae, Streptococcus agalactiae, Chlamydia trachomatis, Trichomonas vaginalis, and Candida spp., as well as their interactions with the host and microbiota in the various niches of the FGT. Taking a holistic approach to identifying fundamental commonalities and differences during these infections could help us to better understand reproductive tract health and improve current prevention and treatment strategies.

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