How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells

Anna Aiello; Mattia Emanuela Ligotti; Maider Garnica; Giulia Accardi; Anna Calabrò; Fanny Pojero; Hugo Arasanz; Ana Bocanegra; Ester Blanco; Luisa Chocarro; Miriam Echaide; Leticia Fernandez-Rubio; Pablo Ramos; Sergio Piñeiro-Hermida; Grazyna Kochan; Nahid Zareian; Farzin Farzaneh; David Escors; Calogero Caruso; Giuseppina Candore

doi:10.3390/ijms23179880

How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells

Anna Aiello, Mattia Emanuela Ligotti, Maider Garnica, Giulia Accardi, Anna Calabrò, Fanny Pojero, Hugo Arasanz, Ana Bocanegra, Ester Blanco, Luisa Chocarro, Miriam Echaide, Leticia Fernandez-Rubio, Pablo Ramos, Sergio Piñeiro-Hermida, Grazyna Kochan, Nahid Zareian, Farzin Farzaneh, David Escors, Calogero Caruso, Giuseppina Candore

Comprehensive Cancer Centre

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

Vaccination, being able to prevent millions of cases of infectious diseases around the world every year, is the most effective medical intervention ever introduced. However, immunosenescence makes vaccines less effective in providing protection to older people. Although most studies explain that this is mainly due to the immunosenescence of T and B cells, the immunosenescence of innate immunity can also be a significant contributing factor. Alterations in function, number, subset, and distribution of blood neutrophils, monocytes, and natural killer and dendritic cells are detected in aging, thus potentially reducing the efficacy of vaccines in older individuals. In this paper, we focus on the immunosenescence of the innate blood immune cells. We discuss possible strategies to counteract the immunosenescence of innate immunity in order to improve the response to vaccination. In particular, we focus on advances in understanding the role and the development of new adjuvants, such as TLR agonists, considered a promising strategy to increase vaccination efficiency in older individuals.

Original language	English
Article number	9880
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	17
DOIs	https://doi.org/10.3390/ijms23179880
Publication status	Published - Sept 2022

Keywords

adjuvants
aging
dendritic cells
immunosenescence
immunostimulation
innate immunity
trained immunity
vaccines

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10.3390/ijms23179880

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Aiello, A., Ligotti, M. E., Garnica, M., Accardi, G., Calabrò, A., Pojero, F., Arasanz, H., Bocanegra, A., Blanco, E., Chocarro, L., Echaide, M., Fernandez-Rubio, L., Ramos, P., Piñeiro-Hermida, S., Kochan, G., Zareian, N., Farzaneh, F., Escors, D., Caruso, C., & Candore, G. (2022). How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells. International Journal of Molecular Sciences, 23(17), Article 9880. https://doi.org/10.3390/ijms23179880

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title = "How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells",

abstract = "Vaccination, being able to prevent millions of cases of infectious diseases around the world every year, is the most effective medical intervention ever introduced. However, immunosenescence makes vaccines less effective in providing protection to older people. Although most studies explain that this is mainly due to the immunosenescence of T and B cells, the immunosenescence of innate immunity can also be a significant contributing factor. Alterations in function, number, subset, and distribution of blood neutrophils, monocytes, and natural killer and dendritic cells are detected in aging, thus potentially reducing the efficacy of vaccines in older individuals. In this paper, we focus on the immunosenescence of the innate blood immune cells. We discuss possible strategies to counteract the immunosenescence of innate immunity in order to improve the response to vaccination. In particular, we focus on advances in understanding the role and the development of new adjuvants, such as TLR agonists, considered a promising strategy to increase vaccination efficiency in older individuals.",

keywords = "adjuvants, aging, dendritic cells, immunosenescence, immunostimulation, innate immunity, trained immunity, vaccines",

author = "Anna Aiello and Ligotti, {Mattia Emanuela} and Maider Garnica and Giulia Accardi and Anna Calabr{\`o} and Fanny Pojero and Hugo Arasanz and Ana Bocanegra and Ester Blanco and Luisa Chocarro and Miriam Echaide and Leticia Fernandez-Rubio and Pablo Ramos and Sergio Pi{\~n}eiro-Hermida and Grazyna Kochan and Nahid Zareian and Farzin Farzaneh and David Escors and Calogero Caruso and Giuseppina Candore",

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year = "2022",

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doi = "10.3390/ijms23179880",

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Aiello, A, Ligotti, ME, Garnica, M, Accardi, G, Calabrò, A, Pojero, F, Arasanz, H, Bocanegra, A, Blanco, E, Chocarro, L, Echaide, M, Fernandez-Rubio, L, Ramos, P, Piñeiro-Hermida, S, Kochan, G, Zareian, N , Farzaneh, F, Escors, D, Caruso, C & Candore, G 2022, 'How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells', International Journal of Molecular Sciences, vol. 23, no. 17, 9880. https://doi.org/10.3390/ijms23179880

TY - JOUR

T1 - How Can We Improve Vaccination Response in Old People? Part I

T2 - Targeting Immunosenescence of Innate Immunity Cells

AU - Aiello, Anna

AU - Ligotti, Mattia Emanuela

AU - Garnica, Maider

AU - Accardi, Giulia

AU - Calabrò, Anna

AU - Pojero, Fanny

AU - Arasanz, Hugo

AU - Bocanegra, Ana

AU - Blanco, Ester

AU - Chocarro, Luisa

AU - Echaide, Miriam

AU - Fernandez-Rubio, Leticia

AU - Ramos, Pablo

AU - Piñeiro-Hermida, Sergio

AU - Kochan, Grazyna

AU - Zareian, Nahid

AU - Farzaneh, Farzin

AU - Escors, David

AU - Caruso, Calogero

AU - Candore, Giuseppina

PY - 2022/9

Y1 - 2022/9

N2 - Vaccination, being able to prevent millions of cases of infectious diseases around the world every year, is the most effective medical intervention ever introduced. However, immunosenescence makes vaccines less effective in providing protection to older people. Although most studies explain that this is mainly due to the immunosenescence of T and B cells, the immunosenescence of innate immunity can also be a significant contributing factor. Alterations in function, number, subset, and distribution of blood neutrophils, monocytes, and natural killer and dendritic cells are detected in aging, thus potentially reducing the efficacy of vaccines in older individuals. In this paper, we focus on the immunosenescence of the innate blood immune cells. We discuss possible strategies to counteract the immunosenescence of innate immunity in order to improve the response to vaccination. In particular, we focus on advances in understanding the role and the development of new adjuvants, such as TLR agonists, considered a promising strategy to increase vaccination efficiency in older individuals.

AB - Vaccination, being able to prevent millions of cases of infectious diseases around the world every year, is the most effective medical intervention ever introduced. However, immunosenescence makes vaccines less effective in providing protection to older people. Although most studies explain that this is mainly due to the immunosenescence of T and B cells, the immunosenescence of innate immunity can also be a significant contributing factor. Alterations in function, number, subset, and distribution of blood neutrophils, monocytes, and natural killer and dendritic cells are detected in aging, thus potentially reducing the efficacy of vaccines in older individuals. In this paper, we focus on the immunosenescence of the innate blood immune cells. We discuss possible strategies to counteract the immunosenescence of innate immunity in order to improve the response to vaccination. In particular, we focus on advances in understanding the role and the development of new adjuvants, such as TLR agonists, considered a promising strategy to increase vaccination efficiency in older individuals.

KW - adjuvants

KW - aging

KW - dendritic cells

KW - immunosenescence

KW - immunostimulation

KW - innate immunity

KW - trained immunity

KW - vaccines

UR - http://www.scopus.com/inward/record.url?scp=85137590418&partnerID=8YFLogxK

U2 - 10.3390/ijms23179880

DO - 10.3390/ijms23179880

M3 - Review article

C2 - 36077278

AN - SCOPUS:85137590418

SN - 1661-6596

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 17

M1 - 9880

ER -

How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells

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Keywords

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