How could we enhance translation of sepsis immunology to inform immunomodulation trials in sepsis?

TY - JOUR

T1 - How could we enhance translation of sepsis immunology to inform immunomodulation trials in sepsis?

AU - Shankar-Hari, Manu

N1 - Export Date: 22 June 2017 CODEN: CRCAF Correspondence Address: Shankar-Hari, M.; Guy's and St Thomas' NHS Foundation TrustUnited Kingdom; email: [email protected]

PY - 2017/5/26

Y1 - 2017/5/26

N2 - Sepsis results in complex alterations to the immune system. Our understanding of how these alterations in immune responses could help characterize extreme immune phenotypes, identify biomarkers with the ability to stratify patients for therapeutic interventions, surrogates in the causal pathway of clinical end-points, and treatable traits are still rudimentary. A methodologically rigorous, consensus-based approach should enrich sepsis immune subpopulations to increase the probability of successful trials.

AB - Sepsis results in complex alterations to the immune system. Our understanding of how these alterations in immune responses could help characterize extreme immune phenotypes, identify biomarkers with the ability to stratify patients for therapeutic interventions, surrogates in the causal pathway of clinical end-points, and treatable traits are still rudimentary. A methodologically rigorous, consensus-based approach should enrich sepsis immune subpopulations to increase the probability of successful trials.

KW - Host response

KW - Immunology

KW - Sepsis

KW - Trials

U2 - 10.1186/s13054-017-1715-0

DO - 10.1186/s13054-017-1715-0

M3 - Editorial

C2 - 28571579

SN - 1364-8535

VL - 21

SP - 125

JO - CRITICAL CARE

JF - CRITICAL CARE

IS - 1

ER -