H2S: A new approach to lifespan enhancement and healthy ageing?

Bedoor Qabazard; Stephen Sturzenbaum

doi:10.1007/978-3-319-18144-8_14

H₂S: A new approach to lifespan enhancement and healthy ageing?

Bedoor Qabazard, Stephen Sturzenbaum

Kuwait University

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Ageing, a progressive structural and functional decline, is considered to be a major risk factor for virtually all ageing-associated pathologies and disabilities, including Alzheimer’s disease, Parkinson’s disease, stroke, diabetes, atherosclerosis and certain cancers. Biogerontology research has now been largely directed towards finding novel drug targets to decelerate the ageing process and attain healthy ageing in order to delay the onset of all ageing-related diseases. H₂S has been reported to exert vasodilatory, antioxidant, anti-apoptotic and anti-inflammatory actions and has been shown to act as a signalling molecule, neuromodulator and cytoprotectant. Intriguingly, H₂S has been reported to regulate cell cycle and survival in healthy cells which suggests that it may regulate cell fate and hence the ageing process. This chapter sets out to provide an overview of the current knowledge regarding the involvement of H₂S in ageing, with a specific focus on the invertebrate model nematode C. elegans.

Original language	English
Pages (from-to)	269-287
Number of pages	19
Journal	Handbook of Experimental Pharmacology
Volume	230
DOIs	https://doi.org/10.1007/978-3-319-18144-8_14
Publication status	Published - 2015

Keywords

Ageing
C. Elegans
H<inf>2</inf>S
Lifespan
Nematode

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-319-18144-8_14

Cite this

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title = "H2S: A new approach to lifespan enhancement and healthy ageing?",

abstract = "Ageing, a progressive structural and functional decline, is considered to be a major risk factor for virtually all ageing-associated pathologies and disabilities, including Alzheimer{\textquoteright}s disease, Parkinson{\textquoteright}s disease, stroke, diabetes, atherosclerosis and certain cancers. Biogerontology research has now been largely directed towards finding novel drug targets to decelerate the ageing process and attain healthy ageing in order to delay the onset of all ageing-related diseases. H2S has been reported to exert vasodilatory, antioxidant, anti-apoptotic and anti-inflammatory actions and has been shown to act as a signalling molecule, neuromodulator and cytoprotectant. Intriguingly, H2S has been reported to regulate cell cycle and survival in healthy cells which suggests that it may regulate cell fate and hence the ageing process. This chapter sets out to provide an overview of the current knowledge regarding the involvement of H2S in ageing, with a specific focus on the invertebrate model nematode C. elegans.",

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