Human attachment security is mediated by the amygdala: Evidence from combined fMRI and psychophysiological measures

E Lemche; Vincent Giampietro; S A Surguladze; E J Amaro; C M Andrew; S C R Williams; M J Brammer; N Lawrence; M A Maier; T A Russell; A Simmons; C Ecker; P Joraschky; M L Phillips

doi:10.1002/hbm.20206

Human attachment security is mediated by the amygdala: Evidence from combined fMRI and psychophysiological measures

E Lemche, Vincent Giampietro, S A Surguladze, E J Amaro, C M Andrew, S C R Williams, M J Brammer, N Lawrence, M A Maier, T A Russell, A Simmons, C Ecker, P Joraschky, M L Phillips

Research output: Contribution to journal › Article › peer-review

102 Citations (Scopus)

Abstract

The neural basis of human attachment security remains unexamined. Using event-related functional magnetic resonance imaging (NRI) and simultaneous recordings of skin conductance levels, we measured neural and autonomic responses in healthy adult individuals during a semantic conceptual priming task measuring human attachment security "by proxy". Performance during a stress but not a neutral prime condition was associated with response in bilateral amygdalae. Furthermore, levels of activity within bilateral amygdalae were highly positively correlated with attachment insecurity and autonomic response during the stress prime condition. We thereby demonstrate a key role of the amygdala in mediating autonomic activity associated with human attachment insecurity.

Original language	English
Article number	N/A
Pages (from-to)	623 - 635
Number of pages	13
Journal	Human Brain Mapping
Volume	27
Issue number	8
DOIs	https://doi.org/10.1002/hbm.20206
Publication status	Published - Aug 2006

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Lemche, E., Giampietro, V., Surguladze, S. A., Amaro, E. J., Andrew, C. M., Williams, S. C. R., Brammer, M. J., Lawrence, N., Maier, M. A., Russell, T. A., Simmons, A., Ecker, C., Joraschky, P., & Phillips, M. L. (2006). Human attachment security is mediated by the amygdala: Evidence from combined fMRI and psychophysiological measures. Human Brain Mapping, 27(8), 623 - 635. Article N/A. https://doi.org/10.1002/hbm.20206

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abstract = "The neural basis of human attachment security remains unexamined. Using event-related functional magnetic resonance imaging (NRI) and simultaneous recordings of skin conductance levels, we measured neural and autonomic responses in healthy adult individuals during a semantic conceptual priming task measuring human attachment security {"}by proxy{"}. Performance during a stress but not a neutral prime condition was associated with response in bilateral amygdalae. Furthermore, levels of activity within bilateral amygdalae were highly positively correlated with attachment insecurity and autonomic response during the stress prime condition. We thereby demonstrate a key role of the amygdala in mediating autonomic activity associated with human attachment insecurity.",

author = "E Lemche and Vincent Giampietro and Surguladze, {S A} and Amaro, {E J} and Andrew, {C M} and Williams, {S C R} and Brammer, {M J} and N Lawrence and Maier, {M A} and Russell, {T A} and A Simmons and C Ecker and P Joraschky and Phillips, {M L}",

year = "2006",

month = aug,

doi = "10.1002/hbm.20206",

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Lemche, E, Giampietro, V , Surguladze, SA, Amaro, EJ, Andrew, CM, Williams, SCR , Brammer, MJ , Lawrence, N, Maier, MA, Russell, TA, Simmons, A , Ecker, C, Joraschky, P & Phillips, ML 2006, 'Human attachment security is mediated by the amygdala: Evidence from combined fMRI and psychophysiological measures', Human Brain Mapping, vol. 27, no. 8, N/A, pp. 623 - 635. https://doi.org/10.1002/hbm.20206

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T1 - Human attachment security is mediated by the amygdala

T2 - Evidence from combined fMRI and psychophysiological measures

AU - Lemche, E

AU - Giampietro, Vincent

AU - Surguladze, S A

AU - Amaro, E J

AU - Andrew, C M

AU - Williams, S C R

AU - Brammer, M J

AU - Lawrence, N

AU - Maier, M A

AU - Russell, T A

AU - Simmons, A

AU - Ecker, C

AU - Joraschky, P

AU - Phillips, M L

PY - 2006/8

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N2 - The neural basis of human attachment security remains unexamined. Using event-related functional magnetic resonance imaging (NRI) and simultaneous recordings of skin conductance levels, we measured neural and autonomic responses in healthy adult individuals during a semantic conceptual priming task measuring human attachment security "by proxy". Performance during a stress but not a neutral prime condition was associated with response in bilateral amygdalae. Furthermore, levels of activity within bilateral amygdalae were highly positively correlated with attachment insecurity and autonomic response during the stress prime condition. We thereby demonstrate a key role of the amygdala in mediating autonomic activity associated with human attachment insecurity.

AB - The neural basis of human attachment security remains unexamined. Using event-related functional magnetic resonance imaging (NRI) and simultaneous recordings of skin conductance levels, we measured neural and autonomic responses in healthy adult individuals during a semantic conceptual priming task measuring human attachment security "by proxy". Performance during a stress but not a neutral prime condition was associated with response in bilateral amygdalae. Furthermore, levels of activity within bilateral amygdalae were highly positively correlated with attachment insecurity and autonomic response during the stress prime condition. We thereby demonstrate a key role of the amygdala in mediating autonomic activity associated with human attachment insecurity.

U2 - 10.1002/hbm.20206

DO - 10.1002/hbm.20206

M3 - Article

VL - 27

SP - 623

EP - 635

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 8

M1 - N/A

ER -

Human attachment security is mediated by the amygdala: Evidence from combined fMRI and psychophysiological measures

Abstract

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