Human cortex development is shaped by molecular and cellular brain systems

IMAGEN Consortium

doi:10.1101/2023.05.05.539537

Human cortex development is shaped by molecular and cellular brain systems

IMAGEN Consortium

Jülich Research Centre
Heinrich Heine University
Max Planck School of Cognition
Max Planck Institute for Human Cognitive and Brain Sciences
Freie Universität Berlin
Humboldt University of Berlin
Berlin Institute of Health
Ecole Normale Supérieure Paris-Saclay
AP-HP, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France
University of Toronto
Charité University of Medicine Berlin
Trinity College Dublin
McGill University
Universitatsklinikum Mannheim
Heidelberg University
Neurospin, Commissariat Energie Atom
Université Paris-Saclay
University of Vermont
University of Nottingham
Physikalisch-Technische Bundesanstalt
Etablissement Public de Santé (EPS) Barthélemy Durand
University of Montreal
University Medical Center Göttingen
TU Dresden
Research Center Jülich

Research output: Working paper/Preprint › Preprint

Abstract

Human brain morphology undergoes complex developmental changes with diverse regional
trajectories. Various biological factors influence cortical thickness development, but human data
are scarce. Building on methodological advances in neuroimaging of large cohorts, we show that
population-based developmental trajectories of cortical thickness unfold along patterns of
molecular and cellular brain organization. During childhood and adolescence, distributions of
dopaminergic receptors, inhibitory neurons, glial cell populations as well as features of brain
metabolism explain up to 50% of variance associated with regional cortical thickness trajectories.
Cortical maturation patterns in later life are best explained by distributions of cholinergic and
glutamatergic systems. These observations are validated in longitudinal data from over 8,000
adolescents, explaining up to 59% of developmental change at population- and 18% at singlesubject
level. Integrating multilevel brain atlases with normative modeling and population
neuroimaging provides a biologically and clinically meaningful path to understand typical and
atypical brain development in living humans.

Original language	English
Publisher	bioRxiv
DOIs	https://doi.org/10.1101/2023.05.05.539537
Publication status	E-pub ahead of print - 10 Aug 2024

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title = "Human cortex development is shaped by molecular and cellular brain systems",

abstract = "Human brain morphology undergoes complex developmental changes with diverse regional trajectories. Various biological factors influence cortical thickness development, but human data are scarce. Building on methodological advances in neuroimaging of large cohorts, we show that population-based developmental trajectories of cortical thickness unfold along patterns of molecular and cellular brain organization. During childhood and adolescence, distributions of dopaminergic receptors, inhibitory neurons, glial cell populations as well as features of brain metabolism explain up to 50\% of variance associated with regional cortical thickness trajectories. Cortical maturation patterns in later life are best explained by distributions of cholinergic and glutamatergic systems. These observations are validated in longitudinal data from over 8,000 adolescents, explaining up to 59\% of developmental change at population- and 18\% at singlesubject level. Integrating multilevel brain atlases with normative modeling and population neuroimaging provides a biologically and clinically meaningful path to understand typical and atypical brain development in living humans.",

author = "Lotter, \{Leon D.\} and Amin Saberi and Hansen, \{Justine Y.\} and Bratislav Misic and Gareth Barker and Bokde, \{Arun L W\} and Sylvane Desrivieres and Herta Flor and Antoine Grigis and Hugh Garavan and Penny Gowland and Andreas Heinz and R{\"u}diger Br{\"u}hl and Jean-Luc Martinot and Marie-Laure Paill{\`e}re-Martinot and Eric Artiges and \{Papadopoulos Orfanos\}, Dimitri and Tom{\'a}{\v s} Paus and Luise Poustka and Sarah Hohmann and Fr{\"o}hner, \{Juliane H.\} and Smolka, \{Michael N.\} and Nilakshi Vaidya and Henrik Walter and Robert Whelan and Gunter Schumann and Frauke Nees and Tobias Banaschewski and Eickhoff, \{Simon B.\} and Juergen Dukart and \{IMAGEN Consortium\}",

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doi = "10.1101/2023.05.05.539537",

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AU - Lotter, Leon D.

AU - Saberi, Amin

AU - Hansen, Justine Y.

AU - Misic, Bratislav

AU - Barker, Gareth

AU - Bokde, Arun L W

AU - Desrivieres, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Brühl, Rüdiger

AU - Martinot, Jean-Luc

AU - Paillère-Martinot, Marie-Laure

AU - Artiges, Eric

AU - Papadopoulos Orfanos, Dimitri

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Fröhner, Juliane H.

AU - Smolka, Michael N.

AU - Vaidya, Nilakshi

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Nees, Frauke

AU - Banaschewski, Tobias

AU - Eickhoff, Simon B.

AU - Dukart, Juergen

AU - IMAGEN Consortium

PY - 2024/8/10

Y1 - 2024/8/10

N2 - Human brain morphology undergoes complex developmental changes with diverse regional trajectories. Various biological factors influence cortical thickness development, but human data are scarce. Building on methodological advances in neuroimaging of large cohorts, we show that population-based developmental trajectories of cortical thickness unfold along patterns of molecular and cellular brain organization. During childhood and adolescence, distributions of dopaminergic receptors, inhibitory neurons, glial cell populations as well as features of brain metabolism explain up to 50% of variance associated with regional cortical thickness trajectories. Cortical maturation patterns in later life are best explained by distributions of cholinergic and glutamatergic systems. These observations are validated in longitudinal data from over 8,000 adolescents, explaining up to 59% of developmental change at population- and 18% at singlesubject level. Integrating multilevel brain atlases with normative modeling and population neuroimaging provides a biologically and clinically meaningful path to understand typical and atypical brain development in living humans.

AB - Human brain morphology undergoes complex developmental changes with diverse regional trajectories. Various biological factors influence cortical thickness development, but human data are scarce. Building on methodological advances in neuroimaging of large cohorts, we show that population-based developmental trajectories of cortical thickness unfold along patterns of molecular and cellular brain organization. During childhood and adolescence, distributions of dopaminergic receptors, inhibitory neurons, glial cell populations as well as features of brain metabolism explain up to 50% of variance associated with regional cortical thickness trajectories. Cortical maturation patterns in later life are best explained by distributions of cholinergic and glutamatergic systems. These observations are validated in longitudinal data from over 8,000 adolescents, explaining up to 59% of developmental change at population- and 18% at singlesubject level. Integrating multilevel brain atlases with normative modeling and population neuroimaging provides a biologically and clinically meaningful path to understand typical and atypical brain development in living humans.

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M3 - Preprint

BT - Human cortex development is shaped by molecular and cellular brain systems

PB - bioRxiv

ER -

Human cortex development is shaped by molecular and cellular brain systems

Abstract

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