Abstract
Protocols for successful differentiation of male and female gametes from induced pluripotent stem cells have been published. Although culture of precursor cells in a natural microenvironment remains necessary to achieve terminal differentiation, the creation of human preimplantation embryos from induced pluripotent stem cell-derived gametes is technically feasible. Such embryos could provide a solution to the scarcity of human cleavage-stage embryos donated for research. Here, we discuss current technology, major research-related ethical concerns and propose the norms that would assure the quality and reliability of such embryos.
| Original language | English |
|---|---|
| Pages (from-to) | 681-691 |
| Number of pages | 11 |
| Journal | Regenerative Medicine |
| Volume | 12 |
| Issue number | 6 |
| Early online date | 4 Oct 2017 |
| DOIs | |
| Publication status | Published - 2017 |
Keywords
- DNA methylation
- embryo
- gametogenesis
- induced pluripotent stem cells
- iPSC
- miRNA
- morphokinetics