Abstract
This chapter reviews evidence for the contribution of genetic factors to bone mineral density (BMD), fracture risk, and response to therapies. Osteoporosis is a condition characterized by low BMD and micro-architectural deterioration leading to increased fracture risk. It is a complex phenotype because its risk is determined by environmental and genetic factors, and possibly their interactions. Although the Fracture Risk Assessment Tool (FRAX) model uses family history of fracture as a risk factor in the risk assessment, no genetic variants have been incorporated into the model. Thus, there is room for genetic research of osteoporosis to improve the prognostic accuracy of these models using genetic variants. Given the ongoing aging of the population worldwide, it is expected that the burden of osteoporosis and osteoporosis-related fractures will become more pronounced in the near future.
| Original language | English |
|---|---|
| Title of host publication | Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism |
| Publisher | WILEY-BLACKWELL |
| Pages | 378-384 |
| Number of pages | 7 |
| ISBN (Electronic) | 9781119266594 |
| ISBN (Print) | 9781119266563 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
Keywords
- Drug mechanisms
- Drug-target indication
- Genetic variation
- Genome-wide association studies
- High-throughput microarrays
- Osteoporosis
- Skeletal genetics