Human intestinal lymphoid tissue in time and space

TY - JOUR

T1 - Human intestinal lymphoid tissue in time and space

AU - Spencer, Jo Michele

AU - Siu, jacqueline HY

AU - Montorsi, Lucia

PY - 2018/12

Y1 - 2018/12

N2 - Observational studies of human tissues have contributed the literature for many years. However, recent initiatives driving human sample collection for research, the acquisition of deep next-generation datasets that enable observational accuracy, and multidisciplinary collaborations between mathematicians and biologists are enabling a new age of observational science. In this issue of Mucosal Immunology, Senda et al 1 describe the quantification of T cell subsets in intestinal lymphoid tissue throughout the gut throughout life and demonstrate the feasibility of developing algorithms to classify gut tissues that may be adapted in the future for diagnosis of pathology.

AB - Observational studies of human tissues have contributed the literature for many years. However, recent initiatives driving human sample collection for research, the acquisition of deep next-generation datasets that enable observational accuracy, and multidisciplinary collaborations between mathematicians and biologists are enabling a new age of observational science. In this issue of Mucosal Immunology, Senda et al 1 describe the quantification of T cell subsets in intestinal lymphoid tissue throughout the gut throughout life and demonstrate the feasibility of developing algorithms to classify gut tissues that may be adapted in the future for diagnosis of pathology.

KW - human gut-associated lymphoid tissue

KW - imaging mass cytometry

U2 - 10.1038/s41385-018-0120-6

DO - 10.1038/s41385-018-0120-6

M3 - Article

SN - 1933-0219

VL - 12

SP - 296

JO - Mucosal Immunology

JF - Mucosal Immunology

IS - 12

ER -