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Human lymphocyte repertoires in ageing

Research output: Contribution to journalLiterature review

Scott D. Boyd, Yi Liu, Chen Wang, Victoria Martin, Deborah K. Dunn-Walters

Original languageEnglish
Article numberN/A
Pages (from-to)511-515
Number of pages5
JournalCurrent Opinion in Immunology
Volume25
Issue number4
DOIs
PublishedAug 2013

King's Authors

Abstract

Deterioration of adaptive immunity with ageing may reflect changes in the repertoire of T cells and B cells available to respond to antigenic challenges, due to altered proportions and absolute numbers of lymphocyte subpopulations as well as changes in the repertoire of antigen receptor genes expressed by these cells. High-throughput DNA sequencing (HIS) now facilitates examination of immunoglobulin and T cell receptor gene rearrangements, and initial studies using these methods to study immune system ageing in humans have demonstrated age-related alterations in the receptor populations within lymphocyte subsets, as well as in repertoires responding to vaccination. Accurate measurement of repertoire diversity remains an experimental challenge. Studies of larger numbers of human subjects, analysis of defined lymphocyte subpopulations including antigen-specific populations, and controlling for factors such as chronic viral infections, will be important for gaining additional understanding of the impact of ageing on human lymphocyte populations.

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