Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

Takashi Namba; Judit Dóczi; Anneline Pinson; Lei Xing; Nereo Kalebic; Michaela Wilsch-Bräuninger; Katherine R. Long; Samir Vaid; Janelle Lauer; Aliona Bogdanova; Barbara Borgonovo; Anna Shevchenko; Patrick Keller; David Drechsel; Teymuras Kurzchalia; Pauline Wimberger; Christos Chinopoulos; Wieland B. Huttner

doi:10.1016/j.neuron.2019.11.027

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

Takashi Namba^*, Judit Dóczi, Anneline Pinson, Lei Xing, Nereo Kalebic, Michaela Wilsch-Bräuninger, Katherine R. Long, Samir Vaid, Janelle Lauer, Aliona Bogdanova, Barbara Borgonovo, Anna Shevchenko, Patrick Keller, David Drechsel, Teymuras Kurzchalia, Pauline Wimberger, Christos Chinopoulos, Wieland B. Huttner

^*Corresponding author for this work

Developmental Neurobiology

Research output: Contribution to journal › Article › peer-review

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Abstract

Namba et al. demonstrate that increased glutaminolysis is essential for the ability of human-specific ARHGAP11B, which is localized in mitochondria, to increase cycling basal progenitor levels in developing neocortex, an effect implicated in the evolutionary expansion of the human neocortex.

Original language	English
Pages (from-to)	867-881.e9
Journal	Neuron
Volume	105
Issue number	5
Early online date	26 Dec 2019
DOIs	https://doi.org/10.1016/j.neuron.2019.11.027
Publication status	Published - 4 Mar 2020

Keywords

evolution
metabolism
neocortex
neural progenitor cells

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10.1016/j.neuron.2019.11.027

Human-Specific ARHGAP11B Acts in_LONG_Published26Deember2019_GREEN AAMAccepted author manuscript, 3.45 MBLicence: CC BY-NC-ND

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Namba, T., Dóczi, J., Pinson, A., Xing, L., Kalebic, N., Wilsch-Bräuninger, M., Long, K. R., Vaid, S., Lauer, J., Bogdanova, A., Borgonovo, B., Shevchenko, A., Keller, P., Drechsel, D., Kurzchalia, T., Wimberger, P., Chinopoulos, C., & Huttner, W. B. (2020). Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis. Neuron, 105(5), 867-881.e9. https://doi.org/10.1016/j.neuron.2019.11.027

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abstract = "Namba et al. demonstrate that increased glutaminolysis is essential for the ability of human-specific ARHGAP11B, which is localized in mitochondria, to increase cycling basal progenitor levels in developing neocortex, an effect implicated in the evolutionary expansion of the human neocortex.",

keywords = "evolution, metabolism, neocortex, neural progenitor cells",

author = "Takashi Namba and Judit D{\'o}czi and Anneline Pinson and Lei Xing and Nereo Kalebic and Michaela Wilsch-Br{\"a}uninger and Long, {Katherine R.} and Samir Vaid and Janelle Lauer and Aliona Bogdanova and Barbara Borgonovo and Anna Shevchenko and Patrick Keller and David Drechsel and Teymuras Kurzchalia and Pauline Wimberger and Christos Chinopoulos and Huttner, {Wieland B.}",

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Namba, T, Dóczi, J, Pinson, A, Xing, L, Kalebic, N, Wilsch-Bräuninger, M, Long, KR, Vaid, S, Lauer, J, Bogdanova, A, Borgonovo, B, Shevchenko, A, Keller, P, Drechsel, D, Kurzchalia, T, Wimberger, P, Chinopoulos, C & Huttner, WB 2020, 'Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis', Neuron, vol. 105, no. 5, pp. 867-881.e9. https://doi.org/10.1016/j.neuron.2019.11.027

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T1 - Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

AU - Namba, Takashi

AU - Dóczi, Judit

AU - Pinson, Anneline

AU - Xing, Lei

AU - Kalebic, Nereo

AU - Wilsch-Bräuninger, Michaela

AU - Long, Katherine R.

AU - Vaid, Samir

AU - Lauer, Janelle

AU - Bogdanova, Aliona

AU - Borgonovo, Barbara

AU - Shevchenko, Anna

AU - Keller, Patrick

AU - Drechsel, David

AU - Kurzchalia, Teymuras

AU - Wimberger, Pauline

AU - Chinopoulos, Christos

AU - Huttner, Wieland B.

PY - 2020/3/4

Y1 - 2020/3/4

N2 - Namba et al. demonstrate that increased glutaminolysis is essential for the ability of human-specific ARHGAP11B, which is localized in mitochondria, to increase cycling basal progenitor levels in developing neocortex, an effect implicated in the evolutionary expansion of the human neocortex.

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KW - metabolism

KW - neocortex

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JO - Neuron

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IS - 5

ER -

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

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