Human telomere biology: pitfalls of moving from the laboratory to epidemiology

A Aviv, A M Valdes, T D Spector

Research output: Contribution to journalLiterature reviewpeer-review

152 Citations (Scopus)

Abstract

Remarkable progress has been made during the last 2 decades in understanding telomere biology at the molecular and cellular levels. Clinical epidemiology research of human telomeres, in contrast, is a discipline just coming into its own. The most important observation in studying human telomere biology is that telomere length is highly variable among humans. Here we explain some of the reasons for this variability and propose several principles that should be considered in conducting epidemiological telomere research. Ignoring these principles could lead to misleading conclusions
Original languageEnglish
Pages (from-to)1424 - 1429
Number of pages6
JournalInternational Journal of Epidemiology
Volume35
Issue number6
DOIs
Publication statusPublished - Dec 2006

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