Human telomere biology: pitfalls of moving from the laboratory to epidemiology

TY - JOUR

T1 - Human telomere biology: pitfalls of moving from the laboratory to epidemiology

AU - Aviv, A

AU - Valdes, A M

AU - Spector, T D

PY - 2006/12

Y1 - 2006/12

N2 - Remarkable progress has been made during the last 2 decades in understanding telomere biology at the molecular and cellular levels. Clinical epidemiology research of human telomeres, in contrast, is a discipline just coming into its own. The most important observation in studying human telomere biology is that telomere length is highly variable among humans. Here we explain some of the reasons for this variability and propose several principles that should be considered in conducting epidemiological telomere research. Ignoring these principles could lead to misleading conclusions

AB - Remarkable progress has been made during the last 2 decades in understanding telomere biology at the molecular and cellular levels. Clinical epidemiology research of human telomeres, in contrast, is a discipline just coming into its own. The most important observation in studying human telomere biology is that telomere length is highly variable among humans. Here we explain some of the reasons for this variability and propose several principles that should be considered in conducting epidemiological telomere research. Ignoring these principles could lead to misleading conclusions

U2 - 10.1093/ije/dyl169

DO - 10.1093/ije/dyl169

M3 - Literature review

VL - 35

SP - 1424

EP - 1429

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 6

ER -