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Humanized Mice as Preclinical Models in Transplantation

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish
Title of host publicationSuppression and Regulation of Immune Responses
PublisherSpringer
Pages177-96
Number of pages20
Volume1371
DOIs
Publication statusPublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1371

King's Authors

Abstract

Animal models have been instrumental in our understanding of the mechanisms of rejection and the testing of novel treatment options in the context of transplantation. We have now entered an exciting era with research on humanized mice driving advances in translational studies and in our understanding of the function of human cells in response to pathogens and cancer as well as the recognition of human allogeneic tissues in vivo. In this chapter we provide a historical overview of humanized mouse models of transplantation to date, outlining the distinct strains and share our experiences in the study of human transplantation immunology.

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