Hybrid Mass Spectrometry: Towards Characterization of Protein Conformational States

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Abstract

A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid MS allowing characterization of challenging biological systems.
Original languageEnglish
JournalTRENDS IN BIOCHEMICAL SCIENCES
DOIs
Publication statusE-pub ahead of print - 17 May 2016

Keywords

  • protein complexes
  • conformational states
  • hybrid approaches
  • mass spectrometry
  • integrative modelling

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