Hydrogel design strategies for drug delivery

Cécile A. Dreiss

doi:10.1016/j.cocis.2020.02.001

Hydrogel design strategies for drug delivery

Cécile A. Dreiss

Institute of Pharmaceutical Science

Research output: Contribution to journal › Review article › peer-review

198 Citations (Scopus)

1427 Downloads (Pure)

Abstract

Hydrogels are water-swollen three-dimensional networks made of polymers, proteins, small molecules or colloids. They constitute a versatile platform for drug delivery because of their capacity to encapsulate and protect drugs and provide sustained and/or remotely programmable spatial and temporal release and have thus generated a substantial amount of research for the delivery of either small active compounds or biopharmaceuticals. This article discusses the features that make hydrogels attractive as matrices for delivery and reviews a range of designs, focussing on studies from recent years, in particular: ‘smart’ hydrogels (responding to temperature, light, magnetic fields, ultrasounds or combined stimuli); recent technologies: 3D printing and microneedles; and closes by discussing polymer-free drug delivery systems: peptides, small molecules and colloids.

Original language	English
Pages (from-to)	1-17
Number of pages	17
Journal	CURRENT OPINION IN COLLOID AND INTERFACE SCIENCE
Volume	48
Early online date	24 Feb 2020
DOIs	https://doi.org/10.1016/j.cocis.2020.02.001
Publication status	Published - Aug 2020

Keywords

3D printing
Controlled release
Drug delivery
Hydrogels
Microneedles
Smart gels
Supramolecular gels

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10.1016/j.cocis.2020.02.001

Hydrogel design strategies for_DREISS_Acc6Feb2020Epub26Feb2020_GREEN AAMAccepted author manuscript, 1.27 MBLicence: CC BY-NC-ND

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abstract = "Hydrogels are water-swollen three-dimensional networks made of polymers, proteins, small molecules or colloids. They constitute a versatile platform for drug delivery because of their capacity to encapsulate and protect drugs and provide sustained and/or remotely programmable spatial and temporal release and have thus generated a substantial amount of research for the delivery of either small active compounds or biopharmaceuticals. This article discusses the features that make hydrogels attractive as matrices for delivery and reviews a range of designs, focussing on studies from recent years, in particular: {\textquoteleft}smart{\textquoteright} hydrogels (responding to temperature, light, magnetic fields, ultrasounds or combined stimuli); recent technologies: 3D printing and microneedles; and closes by discussing polymer-free drug delivery systems: peptides, small molecules and colloids.",

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AB - Hydrogels are water-swollen three-dimensional networks made of polymers, proteins, small molecules or colloids. They constitute a versatile platform for drug delivery because of their capacity to encapsulate and protect drugs and provide sustained and/or remotely programmable spatial and temporal release and have thus generated a substantial amount of research for the delivery of either small active compounds or biopharmaceuticals. This article discusses the features that make hydrogels attractive as matrices for delivery and reviews a range of designs, focussing on studies from recent years, in particular: ‘smart’ hydrogels (responding to temperature, light, magnetic fields, ultrasounds or combined stimuli); recent technologies: 3D printing and microneedles; and closes by discussing polymer-free drug delivery systems: peptides, small molecules and colloids.

KW - 3D printing

KW - Controlled release

KW - Drug delivery

KW - Hydrogels

KW - Microneedles

KW - Smart gels

KW - Supramolecular gels

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DO - 10.1016/j.cocis.2020.02.001

M3 - Review article

SN - 1359-0294

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SP - 1

EP - 17

JO - CURRENT OPINION IN COLLOID AND INTERFACE SCIENCE

JF - CURRENT OPINION IN COLLOID AND INTERFACE SCIENCE

ER -

Hydrogel design strategies for drug delivery

Abstract

Keywords

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