Hyperprolactinaemia in first episode psychosis: A longitudinal assessment

John Lally; Olesya Ajnakina; Brendon Stubbs; Hugh R. Williams; Marco Colizzi; Elena Carra; Sara Fraietta; Poonam Gardner-Sood; Kathryn E. Greenwood; Zerrin Atakan; Valeria Mondelli; Khalida Ismail; Oliver Howes; David M. Taylor; Shubalade Smith; David Hopkins; Robin M. Murray; Fiona Gaughran

doi:10.1016/j.schres.2017.07.037

Hyperprolactinaemia in first episode psychosis: A longitudinal assessment

John Lally, Olesya Ajnakina, Brendon Stubbs, Hugh R. Williams, Marco Colizzi, Elena Carra, Sara Fraietta, Poonam Gardner-Sood, Kathryn E. Greenwood, Zerrin Atakan, Valeria Mondelli, Khalida Ismail, Oliver Howes, David M. Taylor, Shubalade Smith, David Hopkins, Robin M. Murray, Fiona Gaughran

King's College London

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Abstract

Little is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress. Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12 months later. HPL was defined as a serum prolactin level > 410 mIU/L (~ 19.3 ng/ml) for males, and a serum prolactin level > 510 mIU/L (~ 24.1 ng/ml) for females. From a total of 174 people with serum prolactin measurements at study recruitment, 43% (n = 74) had HPL, whilst 27% (n = 21/78) and 27% (n = 26/95) had HPL at 3 and 12 months respectively. We observed higher serum prolactin levels in females versus males (p < 0.001), and in antipsychotic treated (n = 68) versus antipsychotic naïve patients (p < 0.0001). Prolactin levels were consistently raised in FEP patients taking risperidone, amisulpride and FGAs compared to other antipsychotics. No significant relationship was observed between perceived stress scores (β = 7.13, t = 0.21, df = 11, p = 0.0.84 95% CI − 72.91–87.16), or objective life stressors (β = − 21.74, t = − 0.31, df = 8, p = 0.77 95% CI − 218.57–175.09) and serum prolactin. Our study found elevated rates of HPL over the course of the first 12 months of illness. We found no evidence to support the notion that stress is related to elevated serum prolactin at the onset of psychosis.

Original language	English
Pages (from-to)	117-125
Journal	Schizophrenia Research
Volume	189
Early online date	27 Jul 2017
DOIs	https://doi.org/10.1016/j.schres.2017.07.037
Publication status	Published - Nov 2017

Keywords

Prolactin
Hyperprolactinaemia
First episode psychosis (FEP)
Schizophrenia
Antipsychotics
Stress

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10.1016/j.schres.2017.07.037

Hyperprolactinaemia in first episode_LALLY_Publishedonline27July2017_GREEN AAMAccepted author manuscript, 462 KBLicence: CC BY-NC-ND

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Lally, J., Ajnakina, O., Stubbs, B., Williams, H. R., Colizzi, M., Carra, E., Fraietta, S., Gardner-Sood, P., Greenwood, K. E., Atakan, Z., Mondelli, V., Ismail, K., Howes, O., Taylor, D. M., Smith, S., Hopkins, D., Murray, R. M., & Gaughran, F. (2017). Hyperprolactinaemia in first episode psychosis: A longitudinal assessment. Schizophrenia Research, 189, 117-125. https://doi.org/10.1016/j.schres.2017.07.037

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title = "Hyperprolactinaemia in first episode psychosis: A longitudinal assessment",

abstract = "Little is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress. Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12 months later. HPL was defined as a serum prolactin level > 410 mIU/L (~ 19.3 ng/ml) for males, and a serum prolactin level > 510 mIU/L (~ 24.1 ng/ml) for females. From a total of 174 people with serum prolactin measurements at study recruitment, 43% (n = 74) had HPL, whilst 27% (n = 21/78) and 27% (n = 26/95) had HPL at 3 and 12 months respectively. We observed higher serum prolactin levels in females versus males (p < 0.001), and in antipsychotic treated (n = 68) versus antipsychotic na{\"i}ve patients (p < 0.0001). Prolactin levels were consistently raised in FEP patients taking risperidone, amisulpride and FGAs compared to other antipsychotics. No significant relationship was observed between perceived stress scores (β = 7.13, t = 0.21, df = 11, p = 0.0.84 95% CI − 72.91–87.16), or objective life stressors (β = − 21.74, t = − 0.31, df = 8, p = 0.77 95% CI − 218.57–175.09) and serum prolactin. Our study found elevated rates of HPL over the course of the first 12 months of illness. We found no evidence to support the notion that stress is related to elevated serum prolactin at the onset of psychosis.",

keywords = "Prolactin, Hyperprolactinaemia, First episode psychosis (FEP), Schizophrenia, Antipsychotics, Stress",

author = "John Lally and Olesya Ajnakina and Brendon Stubbs and Williams, {Hugh R.} and Marco Colizzi and Elena Carra and Sara Fraietta and Poonam Gardner-Sood and Greenwood, {Kathryn E.} and Zerrin Atakan and Valeria Mondelli and Khalida Ismail and Oliver Howes and Taylor, {David M.} and Shubalade Smith and David Hopkins and Murray, {Robin M.} and Fiona Gaughran",

year = "2017",

month = nov,

doi = "10.1016/j.schres.2017.07.037",

language = "English",

volume = "189",

pages = "117--125",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

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Lally, J , Ajnakina, O , Stubbs, B, Williams, HR, Colizzi, M, Carra, E, Fraietta, S, Gardner-Sood, P , Greenwood, KE, Atakan, Z, Mondelli, V , Ismail, K , Howes, O , Taylor, DM , Smith, S , Hopkins, D , Murray, RM & Gaughran, F 2017, 'Hyperprolactinaemia in first episode psychosis: A longitudinal assessment', Schizophrenia Research, vol. 189, pp. 117-125. https://doi.org/10.1016/j.schres.2017.07.037

TY - JOUR

T1 - Hyperprolactinaemia in first episode psychosis

T2 - A longitudinal assessment

AU - Lally, John

AU - Ajnakina, Olesya

AU - Stubbs, Brendon

AU - Williams, Hugh R.

AU - Colizzi, Marco

AU - Carra, Elena

AU - Fraietta, Sara

AU - Gardner-Sood, Poonam

AU - Greenwood, Kathryn E.

AU - Atakan, Zerrin

AU - Mondelli, Valeria

AU - Ismail, Khalida

AU - Howes, Oliver

AU - Taylor, David M.

AU - Smith, Shubalade

AU - Hopkins, David

AU - Murray, Robin M.

AU - Gaughran, Fiona

PY - 2017/11

Y1 - 2017/11

N2 - Little is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress. Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12 months later. HPL was defined as a serum prolactin level > 410 mIU/L (~ 19.3 ng/ml) for males, and a serum prolactin level > 510 mIU/L (~ 24.1 ng/ml) for females. From a total of 174 people with serum prolactin measurements at study recruitment, 43% (n = 74) had HPL, whilst 27% (n = 21/78) and 27% (n = 26/95) had HPL at 3 and 12 months respectively. We observed higher serum prolactin levels in females versus males (p < 0.001), and in antipsychotic treated (n = 68) versus antipsychotic naïve patients (p < 0.0001). Prolactin levels were consistently raised in FEP patients taking risperidone, amisulpride and FGAs compared to other antipsychotics. No significant relationship was observed between perceived stress scores (β = 7.13, t = 0.21, df = 11, p = 0.0.84 95% CI − 72.91–87.16), or objective life stressors (β = − 21.74, t = − 0.31, df = 8, p = 0.77 95% CI − 218.57–175.09) and serum prolactin. Our study found elevated rates of HPL over the course of the first 12 months of illness. We found no evidence to support the notion that stress is related to elevated serum prolactin at the onset of psychosis.

AB - Little is known about hyperprolactinaemia (HPL) in first episode psychosis (FEP) patients. We investigated longitudinal changes in serum prolactin in FEP, and the relationship between HPL, and antipsychotic medication and stress. Serum prolactin was recorded in FEP patients at recruitment and again, 3 and 12 months later. HPL was defined as a serum prolactin level > 410 mIU/L (~ 19.3 ng/ml) for males, and a serum prolactin level > 510 mIU/L (~ 24.1 ng/ml) for females. From a total of 174 people with serum prolactin measurements at study recruitment, 43% (n = 74) had HPL, whilst 27% (n = 21/78) and 27% (n = 26/95) had HPL at 3 and 12 months respectively. We observed higher serum prolactin levels in females versus males (p < 0.001), and in antipsychotic treated (n = 68) versus antipsychotic naïve patients (p < 0.0001). Prolactin levels were consistently raised in FEP patients taking risperidone, amisulpride and FGAs compared to other antipsychotics. No significant relationship was observed between perceived stress scores (β = 7.13, t = 0.21, df = 11, p = 0.0.84 95% CI − 72.91–87.16), or objective life stressors (β = − 21.74, t = − 0.31, df = 8, p = 0.77 95% CI − 218.57–175.09) and serum prolactin. Our study found elevated rates of HPL over the course of the first 12 months of illness. We found no evidence to support the notion that stress is related to elevated serum prolactin at the onset of psychosis.

KW - Prolactin

KW - Hyperprolactinaemia

KW - First episode psychosis (FEP)

KW - Schizophrenia

KW - Antipsychotics

KW - Stress

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U2 - 10.1016/j.schres.2017.07.037

DO - 10.1016/j.schres.2017.07.037

M3 - Article

SN - 0920-9964

VL - 189

SP - 117

EP - 125

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Hyperprolactinaemia in first episode psychosis: A longitudinal assessment

Abstract

Keywords

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